Month: August 2021

Paying attention to the natural course of disease for a development of gene therapy of inherited retinal diseases

Authors: Wang Fenghua,  Chen Jieqiong,  Sun Xiaodong DOI: 10.3760/cma.j.cn115989-20201007-00677 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 665-669. Abstract                              [View PDF] [Read Full Text] Most inherited retinal diseases (IRDs) severely impair vision and lack effective treatments.With the approval of Luxturna, the world’s first gene […]

Exploring age-related visual dysfunctions and strategies for visual function restoration

Authors: Lyu Fan,  Li Jin,  Pan Anpeng DOI: 10.3760/cma.j.cn115989-20210401-00224 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 670-675. Abstract                              [View PDF] [Read Full Text] According to the international definition on the aging society, China has entered an aging population period.The research and strategies addressed […]

Expression of lncRNA Tsix in a mouse model of N-methyl-D-aspartic acid-induced retinal excitotoxicity and its significance

Authors: Li Yahong,  Geng Chao,  Hei Kaiwen,  Liu Shengnan,  Wang Qi,  Li Xiaorong,  Zhang Yan DOI: 10.3760/cma.j.cn115989-20200119-00033 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 676-685. Abstract                              [View PDF] [Read Full Text] Objective To investigate the damage effect of different concentrations of N-methyl-D-aspartic acid […]

Bioinformatics analysis of transcriptome sequencing after the interference of extremely low frequency electromagnetic field in mouse fibroblasts

Authors: Zhu Maolin,  Zhu Huang DOI: 10.3760/cma.j.cn115989-20200905-00633 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 686-692. Abstract                              [View PDF] [Read Full Text] Objective To analyze the changes in the transcriptome of mouse fibroblasts after exposure to extremely low frequency electromagnetic fields (ELF-EMFs) using next-generation […]

Protective effect of adeno-associated virus vector mediated heme oxygenase-1 overexpression on retinitis pigmentosa in rats

Authors: Liang Yuping,  Chen Weiqi,  Hong Yu,  Gao Xiuyun,  Guo Maosheng DOI: 10.3760/cma.j.cn115989-20201108-00754 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 693-699. Abstract                              [View PDF] [Read Full Text] Objective To investigate the protective effect of adeno-associated virus (AAV) vector-mediated heme oxygenase-1 (HO-1) gene overexpression […]

Relationship between BAP1, FOXO3 and ITPR2 gene expression and metastasis and prognosis of uveal melanoma

Authors: Li Yang,  Feng Yu,  Liu Yueming,  Wei Wenbin DOI: 10.3760/cma.j.cn115989-20200714-00495 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 700-707. Abstract                              [View PDF] [Read Full Text] Objective To explore the potential biomarkers for the metastasis and prognosis of uveal melanoma (UM) from molecular genetics. […]

Genotypic and phenotypic analysis of RHO gene variants in a Chinese Han autosomal dominant retinitis pigmentosa family

Authors: Zhang Yuwei,  Lou Guiyu,  Yang Ke,  Yang Lin,  Zhu Qing,  Lei Bo DOI: 10.3760/cma.j.cn115989-20201217-00848 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 708-713. Abstract                              [View PDF] [Read Full Text] Objective To analyze the pathogenic genes and clinical phenotypes of a Chinese Han family […]

Genetic testing and clinical phenotypic analysis of familial vitreous amyloidosis in two Han Chinese families

Authors: Zheng Wei,  Li Haibo,  Zhang Xueyong,  Zhou Xuezhi,  Chen Yuanyuan,  Mao Junfeng DOI: 10.3760/cma.j.cn115989-20190721-00318 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 714-718. Abstract                              [View PDF] [Read Full Text] Objective To investigate the clinical characteristics of two Han families with familial vitreous amyloidosis […]

Clinical characteristics and genetic mutation analysis in a family with familial vitreous amyloidosis

Authors: Yu Qiang,  Huang Xing,  Yang Zhumin,  Wang Xian DOI: 10.3760/cma.j.cn115989-20190923-00412 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 719-723. Abstract                              [View PDF] [Read Full Text] Objective To analyze the clinical characteristics and transthyretin (TTR) gene mutation of a family with familial vitreous amyloidosis […]

Efficacy evaluation of intravitreal injection of rAAV2-ND4 gene for Leber hereditary optic neuropathy

·Clinical Research· Evaluation of the efficacy of rAAV2-ND4 intravitreal injection for Leber’s hereditary optic neuropathy  Li Xin1, Tian Zhen1, Chen Zhang 1,  Li Bin1 ,2 ,3, Zhang Yong 1 1Department of Ophthalmology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, China; 2Department of Ophthalmology, Tongji Hospital, Tongji Medical College of Huazhong […]