Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration: a Meta-analysis

Objective

To systematically evaluate the association between the hepatic lipase (LIPC) gene rs10468017 polymorphism and susceptibility to age-related macular degeneration (AMD).

Methods

A systematic search was performed in both English databases (PubMed, Embase, EBSCO, Web of Knowledge and Cochrane library) and Chinese databases (CNKI, WanFang, VIP and CBM) from database establishment to December 31, 2019.Literature about LIPC rs10468017 polymorphism and AMD was searched.Odds ratios (OR) and 95% confidence intervals (CI) of allele mode (T and C), heterozygous model (TC and CC) and homozygous model (TT and CC) as well as the correlation between types of AMD and races were calculated using Stata 12.0 software.

Results

Twenty-one studies were included in the Meta-analysis.There were 25 649 AMD patients and 26 294 normal controls.There was a significant correlation between LIPC rs10468017 polymorphism and risk of AMD in different genetic models (T vs. C: OR=0.83, 95% CI: 0.80-0.87; TC vs. CC: OR=0.82, 95% CI: 0.75-0.90; TT vs. CC: OR=0.65, 95% CI: 0.56-0.76). The subgroup analysis showed that the LIPC rs10468017 polymorphism was significantly associated with the risk of early AMD (OR=0.87, 95% CI: 0.78-0.96), advanced AMD (OR=0.83, 95% CI: 0.77-0.88), geographic atrophy (OR=0.79, 95% CI: 0.72-0.87) and choroidal neovascularization (OR=0.83, 95% CI: 0.78-0.89). Stratified analysis by ethnicity showed that there was a significant association between T allele and the decreased risk of AMD in the Caucasian population (early AMD: OR=0.77, 95% CI: 0.67-0.89; advanced AMD: OR=0.80, 95% CI: 0.75-0.87), but not in the Asian population (early AMD: OR=0.98, 95% CI: 0.85-1.13; advanced AMD: OR=0.93, 95% CI: 0.81-1.06).

Conclusions

There is a significant association between T allele of LIPC rs10468017 polymorphism and the reduced risk of AMD, which exists in different subtypes of AMD with certain racial differences.

Age-related macular degeneration; Hepatic lipase gene; Single nucleotide polymorphism; Meta-analysis