Category: 2021, No. 08

Paying attention to the natural course of disease for a development of gene therapy of inherited retinal diseases

Authors: Wang Fenghua,  Chen Jieqiong,  Sun Xiaodong DOI: 10.3760/cma.j.cn115989-20201007-00677 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 665-669. Abstract Most inherited retinal diseases (IRDs) severely impair vision and lack effective treatments.With the approval of Luxturna, the world’s first gene therapy drug for IRDs in 2017 by the U. S.FDA, gene therapy has brought new […]

Exploring age-related visual dysfunctions and strategies for visual function restoration

Authors: Lyu Fan,  Li Jin,  Pan Anpeng DOI: 10.3760/cma.j.cn115989-20210401-00224 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 670-675. Abstract According to the international definition on the aging society, China has entered an aging population period.The research and strategies addressed on age-related health problems have become one of the key parts of the national strategy […]

Expression of lncRNA Tsix in a mouse model of N-methyl-D-aspartic acid-induced retinal excitotoxicity and its significance

Authors: Li Yahong,  Geng Chao,  Hei Kaiwen,  Liu Shengnan,  Wang Qi,  Li Xiaorong,  Zhang Yan DOI: 10.3760/cma.j.cn115989-20200119-00033 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 676-685. Abstract Objective To investigate the damage effect of different concentrations of N-methyl-D-aspartic acid (NMDA) to retinal ganglion cells (RGCs) in mice and explore the expression of long noncoding […]

Bioinformatics analysis of transcriptome sequencing after the interference of extremely low frequency electromagnetic field in mouse fibroblasts

Authors: Zhu Maolin,  Zhu Huang DOI: 10.3760/cma.j.cn115989-20200905-00633 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 686-692. Abstract Objective To analyze the changes in the transcriptome of mouse fibroblasts after exposure to extremely low frequency electromagnetic fields (ELF-EMFs) using next-generation sequencing technology, and to screen out related pathways and genes that might be involved in […]

Protective effect of adeno-associated virus vector mediated heme oxygenase-1 overexpression on retinitis pigmentosa in rats

Authors: Liang Yuping,  Chen Weiqi,  Hong Yu,  Gao Xiuyun,  Guo Maosheng DOI: 10.3760/cma.j.cn115989-20201108-00754 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 693-699. Abstract Objective To investigate the protective effect of adeno-associated virus (AAV) vector-mediated heme oxygenase-1 (HO-1) gene overexpression on retinitis pigmentosa (RP) models in rats. Methods Eighty healthy male SD rats were selected […]

Relationship between BAP1, FOXO3 and ITPR2 gene expression and metastasis and prognosis of uveal melanoma

Authors: Li Yang,  Feng Yu,  Liu Yueming,  Wei Wenbin DOI: 10.3760/cma.j.cn115989-20200714-00495 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 700-707. Abstract Objective To explore the potential biomarkers for the metastasis and prognosis of uveal melanoma (UM) from molecular genetics. Methods The data of 80 UM samples including 18 metastatic cases and 62 non-metastatic cases […]

Genotypic and phenotypic analysis of RHO gene variants in a Chinese Han autosomal dominant retinitis pigmentosa family

Authors: Zhang Yuwei,  Lou Guiyu,  Yang Ke,  Yang Lin,  Zhu Qing,  Lei Bo DOI: 10.3760/cma.j.cn115989-20201217-00848 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 708-713. Abstract Objective To analyze the pathogenic genes and clinical phenotypes of a Chinese Han family with autosomal dominant retinitis pigmentosa (ADRP). Methods A pedigree investigation study was conducted, and a […]

Genetic testing and clinical phenotypic analysis of familial vitreous amyloidosis in two Han Chinese families

Authors: Zheng Wei,  Li Haibo,  Zhang Xueyong,  Zhou Xuezhi,  Chen Yuanyuan,  Mao Junfeng DOI: 10.3760/cma.j.cn115989-20190721-00318 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 714-718. Abstract Objective To investigate the clinical characteristics of two Han families with familial vitreous amyloidosis (FVA) and the gene mutation. Methods A pedigree investigation was performed.Two Han Chinese families with […]

Clinical characteristics and genetic mutation analysis in a family with familial vitreous amyloidosis

Authors: Yu Qiang,  Huang Xing,  Yang Zhumin,  Wang Xian DOI: 10.3760/cma.j.cn115989-20190923-00412 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 719-723. Abstract Objective To analyze the clinical characteristics and transthyretin (TTR) gene mutation of a family with familial vitreous amyloidosis (FVA). Methods A pedigree investigation was performed.The clinical data of 20 family members of a […]

Efficacy evaluation of intravitreal injection of rAAV2-ND4 gene for Leber hereditary optic neuropathy

Authors: Li Xin,  Tian Zhen,  Chen Zhang,  Li Bin,  Zhang Yong DOI: 10.3760/cma.j.cn115989-20210330-00218 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 724-728. Abstract Objective To evaluate the safety and clinical effect of gene therapy for Leber hereditary optic neuropathy (LHON). Methods A multi-center prospective non-randomized controlled trial was conducted.Eighty eyes of 40 LHON patients […]