Category: Review

Research and prospect of inhibitors of mammalian target of rapamycin signaling pathway on the prevention and treatment of posterior capsule opacification

Authors:Chen Jiayu,  Liu Hongling DOI: 10.3760/cma.j.cn115985-20190923-00411 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 360-364. Abstract Posterior capsule opacification (PCO) is the most common complication of extracapsular cataract extraction and intraocular lens implantation in the long-term.After cataract surgery, the content of growth factor in aqueous humor increased, which induced excessive hyperplasia, migration and fibrosis of […]

NLRP3 inflammasome and eye diseases

Authors: Zhang Yujian,  Ji Min,  Guan Huaijin DOI: 10.3760/cma.j.cn115989-20200325-00203 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 365-368. Abstract Nucleotide binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a set of intracellular protein complexes.NLRP3 inflammasome can trigger the activation of caspase-1 and contribute to the maturation of interleukin, and finally result […]

Pathophysiological changes in uninfected eye of unilateral infectious keratitis

Authors: Liu Xintian,  Shi Yan,  Zhang Hong DOI: 10.3760/cma.j.issn.2095-0160.2020.03.011 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 220-223. Abstract Infectious keratitis often occurs in single eye and causes changes in the nervous system, immune system and tear function, which may affect contralateral uninfected eye.Changes in the uninfected eye include a decrease in corneal nerve density […]

Role of the nuclear factor kappa B signaling pathway in the pathogenesis and development of diabetic keratopathy

Authors: Li Weina,  Yang Lingling,  Xie Lixin DOI: 10.3760/cma.j.issn.2095-0160.2020.03.012 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 224-228. Abstract In recent years, with the increasing incidence of diabetes, diabetic keratopathy has gradually attracted more attention from clinicians.Diabetic keratopathy is mainly manifested as delayed corneal epithelial healing, corneal edema, decreased corneal sensitivity, and neurotrophic corneal ulcer.There […]

Research advances regarding fungal biofilms and related ocular diseases

Authors:Wang Hainan,  Zhang Hong DOI: 10.3760/cma.j.issn.2095-0160.2020.03.013 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 229-232. Abstract Clinical studies on refractory fungal infections have revealed that fungal pathogens in infected lesions often existed in the form of biofilms.A biofilm is a complex of microbial communities enclosed in an extracellular matrix.Biofilm formation helps the fungus evade host […]

Association between neurosensory abnormalities and dry eye

Authors: Zhao Zhanlin,  Fu Yao,  Fan Xianqun DOI: 10.3760/cma.j.issn.2095-0160.2020.03.014 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 233-237. Abstract Dry eye affects a large number of people worldwide.A vicious cycle involving multiple factors tends to be implicated in its pathophysiology.Tear secretion is regulated by the sympathetic and parasympathetic nervous systems.Corneal nerve fibers secrete neurotransmitters and […]

Advances in the relationship between insulin-like growth factor system and corneal diseases

Authors: Zhang Jing,  Zhou Qingjun,  Xie Lixin DOI: 10.3760/cma.j.issn.2095-0160.2020.03.015 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 238-242. Abstract Recently, an increasing number of studies on the insulin-like growth factor (IGF) system have been conducted.In addition to its well-known regulation of cell proliferation and differentiation, enhanced metabolic activity, anti-apoptosis, and promotion of cell survival, the […]

Research advances of corneal collagen cross-linking in the treatment of corneal diseases

Authors: Jia Guizhen,  Cheng Mengya,  Wang Linnong DOI: 10.3760/cma.j.issn.2095-0160.2020.03.016 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 245-249. Abstract Corneal collagen cross-linking (CXL) has been proved to be a very safe and effective technique to halt the progression of many cornea diseases, such as ectasia disease, infectious keratitis and ametropia.CXL techniques include conventional CXL, accelerated […]

Research progress in the ocular tropism of respiratory viruses

Authors: Tao Qingqin,  Li Xiaorong,  Zhang Xiaomin DOI: 10.3760/cma.j.issn.2095-0160.2020.03.017 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 250-253. Abstract There are about 200 kinds of respiratory viruses that can infect human.Some viruses can not only enter the human body through respiratory tract to cause infection, but also can cause eye infectious diseases first through eye […]

Advance in research of beta coronavirus receptors on ocular surface

Authors: Yin Xiaolei,  Zhang Jinping DOI: 10.3760/cma.j.cn115989-20200223-00098 Published 2020-03-10 Cite as Chin J Exp Ophthalmol, 2020,38(03): 254-256. Abstract 2019-Novel coronavirus (2019-nCoV) caused an outbreak of corona virus disease 2019 (COVID-19) from December 2019 in China.2019-nCoV which was identified as a kind of beta coronavirus belongs to one of four coronavirus genera.Except 2019-nCoV, two other beta coronavirus, […]