Category: Review

Application of antisense oligonucleotide in the treatment of inherited retinal dystrophy

Authors: Li Wuyi,  Sui Ruifang DOI: 10.3760/cma.j.cn115989-20210128-00074 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 67-72. Abstract Gene therapy is expected to restore the function of genetic material fundamentally and it has become a new trend in inherited retinal dystrophy treatment. Antisense oligonucleotide (AON) is a kind of small molecule nucleic acid drug, which […]

NLRP3 inflammasome and its role in age-related macular degeneration

Authors: Chen Lu,  Xie Ping,  Hu Zizhong DOI: 10.3760/cma.j.cn115989-20210922-00527 Published 2022-01-10 Cite as Chin J Exp Ophthalmol, 2022, 40(1): 73-77. Abstract Age-related macular degeneration (AMD), the leading cause of central vision loss among people aged 50 years and older, is one of the major eye diseases causing blindness in the world. Clinically, advanced AMD is […]

Research progress of purinergic signaling in dry age-related macular degeneration

Authors: Hu Yifan,  Sun Xiaodong DOI: 10.3760/cma.j.cn115989-20190717-00316 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 78-82. Abstract Age-related macular degeneration (AMD) is one of the major causes of visual loss in people over 65 years of age. There is limited treatment for dry AMD, because of its complex mechanism. Purinergic signaling has the functions […]

Application of artificial intelligence in ophthalmic optical coherence tomography

Authors: Duan Kairui,  Zhang Hong DOI: 10.3760/cma.j.cn115989-20191231-00566 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 83-87. Abstract Artificial intelligence (AI) has become the forefront of research in computer science, which has been widely used in the medical field. Ophthalmology is a discipline highly dependent on imaging inspection. AI has great advantages in image recognition.The […]

Progress of treatment for large idiopathic macular holes

Authors: Fan Xiaoe,  Ren Xinjun,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20190129-00039 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 88-92. Abstract Size of the macular hole (MH) is an important factor affecting the treatment of MH. MH with a diameter >400 mm was defined as large MH. Pars plana vitrectomy (PPV) combined with internal limiting membrane […]

Research progress of metabolomics in diabetic retinopathy

Authors: Zhang Luyuan,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20201203-00819 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 93-96. Abstract Diabetic retinopathy (DR) is one of the serious complications of diabetes, and its complex pathogenesis has not been completely clarified yet. Metabolic changes are closely related to phenotypes and metabolomics analysis can indicate the biochemical status of […]

Intraoperative complications and treatment in femtosecond laser small incision lenticule extraction

Authors: Ma Jiaonan,  Wang Yan DOI: 10.3760/cma.j.cn115989-20210310-00158 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1104-1108. Abstract As a relatively new procedure, femtosecond laser small incision lenticule extraction (SMIIE) is still in its initial stage.Despite the safety, efficacy, predictability and stability it has showed in refractive error correction, there are still reports of intraoperative […]

Progress of scleral cross-linking in the treatment of pathological myopia and glaucoma

Authors: Cai Ziyan,  Liu Ke,  Duan Xuanchu DOI: 10.3760/cma.j.cn115989-20191107-00485 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1109-1114. Abstract Myopia is a common eye disease, and pathological myopia is mainly caused by abnormal axial elongation.The weakening of scleral biomechanics is one of the important characteristics of pathological myopia.In recent years, preventing the growth of […]

Relationship between human eye aberration compensation and visual quality

Authors: Zhao Xinheng,  Wang Yan,  Zhang Lin DOI: 10.3760/cma.j.cn115989-20191126-00512 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1115-1118. Abstract Wavefront aberration is an evaluation index of objective visual quality.In recent years, the relationship between the wavefront aberration compensation in human eyes and the visual quality has been paid more and more attention.There is a […]

Recent advances and perspectives in proteomic studies of high myopia

Authors: Xue Min,  Ren Xinjun,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20190423-00199 Published 2021-12-10 Cite asChin J Exp Ophthalmol, 2021, 39(12): 1119-1123. Abstract As one of the main causes of low vision and blindness in the world, high myopia has become increasingly serious and caused heavy economic and social burden.However, its pathogenesis is complex and has not been […]