CJEO Journal

Authors:Liu Wenhui, Gao Jingzhao, Su Lin, Li Xiaorong Corresponding author: Li Xiaorong , Email: xiaorli@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260331-00151 ABSTRACT Oxygen-induced retinopathy (OIR) is an important animal model for retinal neovascular diseases. In recent years, increasing evidence has shown that alterations in the retinal immune microenvironment are involved throughout the development and progression of OIR, among which myeloid immune cells, such as […]

Research progress on neuroimmune interactions in diabetic retinopathy

Authors:Zhang Danlei, Hou Shengping Corresponding author: Hou Shengping, Email: sphou828@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260422-00186 ABSTRACT Diabetic retinopathy (DR) is a common microvascular complication of diabetes and one of the main blinding eye diseases. Recent studies have shown that retinal neurodegenerative changes and chronic low-grade inflammation can occur in the early stage of DR and participate in the progression of the […]

Choroidal neovascularization: multipathway pathological mechanisms and novel synergistic therapeutic strategies

Authors:Yao Mudi, Liu Qian, Yan Biao Corresponding author: Yan Biao, Email: yanbiao@sjtu.edu.cn Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20251215-00428 ABSTRACT Choroidal neovascularization (CNV) represents a common blinding terminal pathological change across various fundus diseases. Although anti-vascular endothelial growth factor (VEGF) therapy has become the standard of care, long-term clinical practice has revealed significant limitations, including drug resistance, the burden of frequent injections, and the […]

Advances in the application of adaptive optics retinal imaging in diabetic retinopathy

Authors:Wang Xufan, Bai Wen, Yao Jin Corresponding author: Yao Jin, Email: dryaojin@126.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260407-00164 ABSTRACT Diabetic retinopathy (DR) is a common microvascular complication in patients with diabetes. It is also an important cause of visual impairment in working-age adults. Color fundus photography, fundus fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography are commonly used for DR screening, […]

Gene therapy in retinal neovascular disease: a recent update

Authors: Li Yuntong, Yan Wenjia, Ding Xiaoyan Corresponding author: Ding Xiaoyan, Email: dingxiaoyan@gzzoc.com Published:2026-09-10 DOI: 10.3760/cma.j.cn115989-20230324-00101 ABSTRACT Retinal diseases characterized by neovascularization or vascular leakage, such as neovascular age-related macular degeneration, diabetic retinopathy, and secondary choroidal neovascularization, are common retinal vascular disorders that can result in irreversible vision loss. Currently, the standard treatment for these retinal vascular disorders is […]

Gene research progress of Fuchs endothelial corneal dystrophy

Authors:Gao Fengjie, Guan Huaijin, Ji Min Corresponding author:Ji Min , Email:amyji1234@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20241113-00309 ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is a bilateral inherited corneal disorder characterized by irreversible degeneration of the corneal endothelium. Clinically, it manifests as a progressive loss of corneal endothelial cells, stromal edema, and gradual deterioration of visual function. In advanced stages, corneal transplantation remains the […]

Research progress of tetrahedral framework nucleic acids in ophthalmology

Authors:Zhang Pengcheng, Wang Liqiang, Liu Anqi Corresponding author: Liu Anqi, Email:liuanqi301@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250411-00114 ABSTRACT In the field of ophthalmology, particularly in tissue regeneration, although gene therapy, stem cells, and drug development are highly regarded, their clinical translation still faces bottlenecks such as easy degradation in vivo, low delivery efficiency, and lack of targeting. In recent years, nucleic acid nanomaterials […]

Retinal structure and function in the rd10 mouse model of retinitis pigmentosa: current status and future perspectives

Authors:Yang Hongli, Zhang Hui, Li Xiaorong Corresponding author: Li Xiaorong, Email:lixiaorong@tmu.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20240303-00061 ABSTRACT Retinitis pigmentosa (RP) is a genetically inherited disorder characterized by the progressive degeneration of photoreceptors and a subsequent decline in visual function. Although various treatments, such as neuroprotective drugs, gene repair or gene therapy, and transplantation of stem cells and their derivatives, have been explored, […]

Research progress on targeted regulation of regulatory T cells in new strategies for dry eye treatment

Authors:Liu Lirui, Xu Wen Corresponding author: Xu Wen, Email:xuwen2003@zju.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20230720-00044 ABSTRACT Dry eye is a multifactorial ocular surface disease characterized by the loss of tear film homeostasis caused by many factors, which is often accompanied by ocular surface discomfort, and the related immune mechanism is involved in its occurrence and development. Regulatory T cells (Tregs) are the […]

Research progress of drug-loaded hydrogel in the treatment of uveitis