Authors:Gao Fengjie, Guan Huaijin, Ji Min Corresponding author:Ji Min , Email:amyji1234@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20241113-00309 ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is a bilateral inherited corneal disorder characterized by irreversible degeneration of the corneal endothelium. Clinically, it manifests as a progressive loss of corneal endothelial cells, stromal edema, and gradual deterioration of visual function. In advanced stages, corneal transplantation remains the […]
Category: Review
Research progress of tetrahedral framework nucleic acids in ophthalmology
Authors:Zhang Pengcheng, Wang Liqiang, Liu Anqi Corresponding author: Liu Anqi, Email:liuanqi301@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250411-00114 ABSTRACT In the field of ophthalmology, particularly in tissue regeneration, although gene therapy, stem cells, and drug development are highly regarded, their clinical translation still faces bottlenecks such as easy degradation in vivo, low delivery efficiency, and lack of targeting. In recent years, nucleic acid nanomaterials […]
Retinal structure and function in the rd10 mouse model of retinitis pigmentosa: current status and future perspectives
Authors:Yang Hongli, Zhang Hui, Li Xiaorong Corresponding author: Li Xiaorong, Email:lixiaorong@tmu.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20240303-00061 ABSTRACT Retinitis pigmentosa (RP) is a genetically inherited disorder characterized by the progressive degeneration of photoreceptors and a subsequent decline in visual function. Although various treatments, such as neuroprotective drugs, gene repair or gene therapy, and transplantation of stem cells and their derivatives, have been explored, […]
Research progress on targeted regulation of regulatory T cells in new strategies for dry eye treatment
Authors:Liu Lirui, Xu Wen Corresponding author: Xu Wen, Email:xuwen2003@zju.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20230720-00044 ABSTRACT Dry eye is a multifactorial ocular surface disease characterized by the loss of tear film homeostasis caused by many factors, which is often accompanied by ocular surface discomfort, and the related immune mechanism is involved in its occurrence and development. Regulatory T cells (Tregs) are the […]
Research progress of drug-loaded hydrogel in the treatment of uveitis
Authors:Wang Qimiao, Shan Mengyuan, Wang Yan Corresponding author: Wang Yan, Email:wangyan7143@vip.sina.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20231010-00122 ABSTRACT Uveitis is a potentially blinding ocular inflammatory disease characterized by a prolonged course and a high recurrence rate. The clinical treatment of uveitis is limited by the blood-ocular barrier, which reduces the absorption and bioavailability of topically administered drugs. Frequent administration […]
Research progress on the immune mechanism of corneal neovascularization
Authors:Liu Mengxin, Yan Chunxiao,Zhang Lijun Corresponding author: Zhang Lijun, Email: lijunzhangw@sina.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240923-00266 ABSTRACT Corneal neovascularization (CNV) is a common pathological change in many eye diseases, such as infections, inflammation, hypoxia, degeneration, and trauma, which can cause serious visual impairment. Inflammation is the core mechanism of CNV, and various immune cells (macrophages, neutrophils, T cells, and antigen-presenting cells) […]
Oxidative stress-induced mechanisms in corneal neovascularization and targeted therapeutic approaches
Authors:Deng Qian, Wan Shanshan, Yang Yanning Corresponding author: Yang Yanning, Email: yangyanning@whu.edu.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240229-00056 ABSTRACT Corneal neovascularization (CNV) is an ocular surface disorder caused by a variety of diseases, including inflammation, trauma, malnutrition, wearing of corneal contact lenses, etc. Oxidative stress refers to the excessive production of reactive oxygen species or reactive nitrogen species in […]
The anatomy, physiology and mechanism of vortex veins in ocular diseases associated with vortex vein dysfunction
Authors: Yang Xieke, Yan Ming, Song Yanping Corresponding author: Song Yanping, Email: drsongyanping@163.com Published:2026-07-10 DOI: 10.3760/cma.j.cn115989-20250303-00061 ABSTRACT The vortex vein, serving as the sole drainage pathway for the choroidal veins, plays a pivotal role in the pathogenesis of various ocular diseases due to its anatomical variations and physiological dysfunctions. This article systematically reviews the anatomical and physiological characteristics of the […]
Current research status of retinal ciliopathy
Authors: Fan Xue, Rong Weining Corresponding author: Rong Weining, Email: moc.621624gniniewgnor Published:2026-07-10 DOI: 10.3760/cma.j.cn115989-20230731-00054 ABSTRACT Cilia widely exist in most cell types of the human body, and the dysfunction of cilia can affect various organs. The outer segment of the photoreceptor is a kind of highly differentiated primary sensory cilium, and its structure and function […]
Application of molecular diagnostic technology in the diagnosis of infectious eye diseases
Authors: Li Panpan, Guan Huaijin Corresponding author: Guan Huaijin, Email: guanhuaijinleye@126.com Published:2026-07-10 DOI: 10.3760/cma.j.cn115989-20231124-00184 ABSTRACT The clinical diagnosis of infectious diseases mainly relies on the isolation and culture of pathogenic microorganisms, but many infectious eye diseases have problems such as acute onset, difficulty in obtaining samples, and difficulty in diagnosis. Compared with traditional microbial culture, […]