Category: Review

Application of CRISPR/Cas9 gene editing technology in the construction of animal models of ophthalmic diseases

Authors: Ma Xiaochen,  Liu Hongling DOI: 10.3760/cma.j.cn115989-20190930-00425 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 972-975. Abstract                                       [View PDF] [Read Full Text]  The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated endonuclease 9 (Cas9) technology is a gene editing technology that uses […]

Progress in the research on clinical features of Bestrophinopathies and mutations in BEST1 gene

Authors: Yang Shangying,  Sheng Xunlun DOI: 10.3760/cma.j.cn115989-20200921-00659 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 976-980. Abstract                                       [View PDF] [Read Full Text]  Bestrophinopathies are a group of inherited macular dystrophies caused by BEST1 gene mutations including Best vitelliform macular dystrophy, adult-onset […]

Epigenetic regulation and retinal degenerative diseases

Authors: Zhang Hua,  Pang Jijing DOI: 10.3760/cma.j.cn115989-20191015-00442 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 981-985. Abstract                                     [View PDF] [Read Full Text]  Epigenetics pertains to heritable alterations in gene expression when the nucleotide sequence remains unchanged.Epigenetic regulation […]

Role of microRNA-21 in the occurrence and development of ophthalmic diseases

Authors: Sun Jijun,  Ruan Qingguo,  Shi Weiyun DOI: 10.3760/cma.j.cn115989-20191007-00428 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 986-991. Abstract                                      [View PDF] [Read Full Text]  MicroRNA (miRNA) is a short noncoding RNA, which can regulate gene expression.miR-21 is one of the human miRNAs […]

Research progress on regulation of lncRNA in age-related ophthalmopathy

Authors: Cheng Tianyu,  Guan Huaijin DOI: 10.3760/cma.j.cn115989-20190125-00035 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 992-995. Abstract                                     [View PDF] [Read Full Text]  Long non-coding RNA (lncRNA) is a class of transcripts longer than 200 nucleotides, which do not […]

Advances in rodent models of retinal neovascularization

Authors: Xu Qianhui,  Chen Jun,  Shao Yi DOI: 10.3760/cma.j.cn115989-20200211-00064 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 996-998. Abstract                                       [View PDF]  [Read Full Text]  Retinal neovascularization (RNV) originating from retinal blood vessels is one of the main pathological features of many ocular […]

Expression and determination of biomarkers in diabetic retinopathy

Authors: Jiang Yilin,  Zhang Xiaomin,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20200417-00269 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 859-863. Abstract                                       [View PDF] [Read Full Text] Diabetic retinopathy (DR) is a kind of common vascular complications in diabetes and one of the leading […]

Research progress of inflammatory cytokines in intraocular fluid of diabetic macular edema

Authors: Hong Yiyi,  Sun Xufang DOI: 10.3760/cma.j.cn115989-20200610-00417 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 864-868. Abstract                                       [View PDF] [Read Full Text] Diabetic macular edema is a common complication of diabetic retinopathy, and is the main cause of vision decline.Antivascular endothelial […]

Application of proteomics in exploring the inflammatory biomarkers of diabetic retinopathy

Authors: Xu Manhong,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20200428-00294 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 869-873. Abstract                                       [View PDF] [Read Full Text] Diabetic retinopathy (DR) is a common neurovascular complication of diabetes patients, which seriously threatens the vision health of working-age […]

Progress on the phenotype of human corneal stromal cells

Authors: Yang Yi,  Niu Yang,  Yuan Ling DOI: 10.3760/cma.j.cn115989-20200626-00455 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 874-879. Abstract                                       [View PDF] [Read Full Text] Human corneal stromal cells (HCSCs), a type of resting neural crest mesenchymal cell, are highly specialized transparent […]