Authors: Zhang Hui, Zhang Xiaomin, Li Xiaorong DOI: 10.3760/cma.j.cn115989-20200424-00285 Published 2020-09-10 Cite as Chin J Exp Ophthalmol, 2020,38(09): 799-803. Abstract Exosomes are small extracellular vesicles secreted by cells and carry many biological molecules, such as mRNA, microRNA, proteins, and transcription factors.Exosomes play a role in mediating intercellular communication in normal physiological processes.In the pathological state, […]
Category: Review
Application of machine learning in auxiliary diagnosis of corneal related diseases
Authors: Zhang Zijun, Liang Qingfeng DOI: 10.3760/cma.j.cn115989-20200201-00045 Published 2020-09-10 Cite as Chin J Exp Ophthalmol, 2020,38(09): 804-808. Abstract Machine learning, as the main technical direction of artificial intelligence, can help ophthalmologists to interpret and analyze the large amount of data generated by imaging equipment, and also simplify the diagnosis and treatment process.The early diagnosis and […]
Application of single-cell RNA sequencing in visual system
Authors: Liu Yifan, Shen Yin DOI: 10.3760/cma.j.cn115989-20200509-00325 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 704-709. Abstract Single-cell RNA sequencing (scRNA-seq) is an emerging technology that observes transcriptomes’ differences between individual cells at the cellular level.The basic strategy is to capture single cells and lysis the cells to get mRNA, then amplify them after reversing […]
Review and analysis on knockout mouse models with cataract
Authors: Wu Zehua, Liu Xiangyuan, Li Yuying, Zhong Zilin, Chen Jianjun DOI: 10.3760/cma.j.cn115989-20190227-00087 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 710-714. Abstract Cataract is the leading cause of blindness worldwide, which is a generally clinical and genetic heterogeneity eye disease.To date, more than 50 genes have been reported to be associated with congenital cataract.While […]
Advances of genetics of age-related macular degeneration
Authors: Xu Jingjing, Hu Yuntao DOI: 10.3760/cma.j.cn115989-20200509-00324 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 715-720. Abstract Age-related macular degeneration (AMD) is one of the leading causes of blindness for the elderly over 50, characterized by loss of central vision irreversibly.The mechanism of AMD is not clear.In recent years, researchers have screened a variety of […]
Research progress of survivin gene and eye diseases
Authors: Wang Xiaocong, Tan Wei DOI: 10.3760/cma.j.cn115989-20200509-00322 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 721-725. Abstract Survivin is a member of inhibitors of apoptosis protein family, compared with other members, survivin has a unique baculovirus apoptosis inhibitory protein—inhibitor of apoptosis proteins (IAP) baculovirus IAP repeat (BIR) and alpha helix molecular structure, determines its important […]
Advances in genetic research of FOXL2 in patients with blepharophimosis-ptosis-epicanthus inversus syndrome
Authors: Yang Lin, Ke Min, Chen Xiaomin DOI: 10.3760/cma.j.cn115989-20200509-00323 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 726-728. Abstract Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease, which has been divided into two types according to whether it involves premature ovarian failure.BPES is characterized by typical eyelid malformations, including a narrowed horizontal palpehral […]
Advances in animal models of retinal vein occlusion induced by laser photocoagulation and photodynamic therapy
Authors: Pei Chao, Feng Jun DOI: 10.3760/cma.j.cn115985-2019-0409-00174 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 621-624. Abstract Retinal vein occlusion (RVO) is a common retinal vascular disease that causes vision loss.The etiology of RVO is complex and its pathogenesis has not yet been fully elucidated.With the development of modern medical technology, there are more and […]
Predictive value of OCT parameters to prognosis of anti-VEGF therapy for macular edema secondary to retinal vein occlusion
Authors: Tang Fusheng, Lu Jianmin, Ma Xiang DOI: 10.3760/cma.j.cn115989-20200519-00358 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 625-628. Abstract Macular edema secondary to retinal vein occlusion (RVO) is the leading cause of visual impairment in patients with RVO.Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is the first-line treatment for RVO and most of […]
Surgery therapy for polypoidal choroidal vasculopathy
Authors: Jiao Mingfei, Li Xiaorong, Hu Bojie DOI: 10.3760/cma.j.cn115985-20200519-00354 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 629-632. Abstract With the development of intraocular injection of anti-vascular endothelial growth factor (VEGF) drugs, early treatment of polypoidal choroidal vasculopathy (PCV) has more understanding and development.Once PCV combined with vitreous hemorrhage, treatment becomes much more difficult.The causes […]