Category: Current Issue

The opportunities of metabolic windows for early diagnosis and precise prevention and treatment of diabetic retinopathy

Authors: Zhang Fang,  Xu Xun DOI: 10.3760/cma.j.cn115989-20211209-00678 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 1-5. Abstract Diabetes mellitus (DM) is a chronic metabolic disease caused by multiple etiologies. Diabetic retinopathy (DR), as a primary ocular complication of DM, is the leading cause of blindness among working-age adults in the world.With the rapid increase […]

Effect of ROS/NLRP3/Caspase-1 signaling pathway on the apoptosis of retinal pigment epithelial cells induced by high glucose

Authors: Li Hongsong,  Li Rong,  Wang Lijun,  Liao Dingying,  Wang Jianming DOI: 10.3760/cma.j.cn115989-20210420-00267-1 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 6-12. Abstract Objective To investigate the effect of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome on the proliferation and apoptosis of human retinal pigment epithelial cell line ARPE-19 exposed to […]

Proteomic analysis of optic nerve in the rat model of non-arteritic anterior ischemic optic neuropathy

Authors: Hu Liying,  Li Zhiqing,  Shao Xianfeng,  Guo Xiaoxue,  Yu Dawei,  Dong Lijie,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20201104-00745 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 13-20. Abstract Objective To quantitatively analyze the protein expression changes of the optic nerve in an SD rat model of non-arteritic anterior ischemic optic neuropathy (NAION), and to make […]

Effect of human umbilical cord derived mesenchymal stem cells on apoptosis of rat retinal ganglion cells under high glucose and on the regulation of p38MAPK pathway

Authors: Liu Xi,  Sun Xiaoping,  Yang Jianwei,  Zhu Dongmei,  Wang Yuan DOI: 10.3760/cma.j.cn115989-20200804-00559 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 21-28. Abstract Objective To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSC) on the apoptosis of retinal ganglion cells (RGCs) in diabetic retinopathy (DR) model rats and on the regulation […]

Expression and significance of Jagged1 in fibrovascular membranes of proliferative diabetic retinopathy

Authors: Guo Qingmin,  Meng Xuxia,  Yang Kun,  Yu Chuan DOI: 10.3760/cma.j.cn115989-20191018-00453 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 29-34. Abstract Objective To observe the expression and significance of Jagged1 in fibrovascular membranes of proliferative diabetic retinopathy (PDR). Methods Sixty preretinal fibrovascular membrane specimens collected from fifty-seven patients (60 eyes) with PDR during vitrectomy […]

Application value assessment of intraoperative optical coherence tomography in vitreoretinal surgery

Authors: Tao Jiwei,  Chen Huan,  Shen Lijun,  Lin Jingjing,  Chen Yiqi,  Mao Jianbo,  Fang Jia DOI: 10.3760/cma.j.cn115989-20190715-00309 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 35-40. Abstract Objective To evaluate the application of intraoperative optical coherence tomography (iOCT) in vitreoretinal surgery. Methods An observational case series study was conducted.A total of 316 patients (316 […]

Comparison of efficacy between intravitreal injection of conbercept with and without macular photocoagulation for diabetic macular edema

Authors: Jiang Li,  Luo Xiaoling,  Qin Bo,  Deng Tingming,  Yang Mingming DOI: 10.3760/cma.j.cn115989-20201104-00746 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 41-46. Abstract Objective To compare the clinical efficiency and safety between intravitreal injection of conbercept with and without macular photocoagulation for diabetic macular edema (DME). Methods A non-random controlled study was conducted.Sixty patients […]

Comparison of long-term macular morphology after laser retinal photocoagulation and anti-VEGF therapy and their effects on vision prognosis for type 1 ROP

Authors: Guo Lili,  Cheng Yong,  Deng Xun,  Linghu Dandan,  Zhu Xuemei,  Shi Xuan,  Li Xiaoxin,  Liang Jianhong DOI: 10.3760/cma.j.cn115989-20210913-00508 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 47-53. Abstract Objective To evaluate and compare the foveal microvascular morphology and central foveal thickness (CFT) after laser retinal photocoagulation and intravitreal injection of anti-vascular endothelial growth […]

Quantification analysis of macular microcirculation in early diabetic patients and its correlation with visual acuity

Authors: Xu Min,  Nie Lujuan,  Zhang Xue,  Chen Fang DOI: 10.3760/cma.j.cn115989-20210419-00263 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 54-61. Abstract Objective To analyze the change of macular microcirculation in early diabetic patients and its correlation with visual acuity. Methods A cross-sectional study was performed.Seventy-five eyes from 75 patients with non-diabetic retinopathy (NDR) and […]

Effects of internal limiting membrane peeling on post-vitrectomy epiretinal membrane and visual prognosis of rhegmatogenous retinal detachment

Authors: Fu Yan,  Xie Tianhao,  Yang Na,  Li Liying,  Zhang Yueling,  Gu Zhaohui DOI: 10.3760/cma.j.cn115989-20190428-00188 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 62-66. Abstract Objective To analyze the effect of vitrectomy combined with internal limiting membrane (ILM) peeling on the prevention of post-vitrectomy epiretinal membrane (ERM) in macular-off rhegmatogenous retinal detachment (RRD) and […]