Category: Clinical Science

Evaluation of an aided diagnosis system for vitreous and retinal diseases by analyzing B-scan ultrasound images based on deep convolutional neural network

Authors: Yu Yi,  Zhou Yiwen,  Chen Di,  Hu Shan,  Yang Yanning DOI: 10.3760/cma.j.cn115989-20210114-00037 Published 2021-09-10 Cite asChin J Exp Ophthalmol, 2021, 39(9): 792-797. Abstract Objective To explore the clinical value of a diagnostic system of ophthalmic B-scan ultrasound images based on deep convolutional neural network. Methods A total of 3 600 ophthalmic B-scan ultrasound images […]

Development and clinical evaluation of intelligent vision examination and management system based on mobile terminal

Authors: Xiang Yifan,  Chen Jingjing,  Hu Weiling,  Xu Fabao,  Lin Haotian DOI: 10.3760/cma.j.cn115989-20200522-00367 Published 2021-09-10 Cite asChin J Exp Ophthalmol, 2021, 39(9): 798-802. Abstract Objective To develop an intelligent vision examination and management system based on mobile terminal, and evaluate its practical application. Methods A diagnostic test study was adopted.Fifty children and adolescents (100 eyes) […]

Risk factors of postoperative vitreous hemorrhage after pars plana vitrectomy for proliferative diabetic retinopathy

Authors: Fan Xiaoe,  Ke Yifeng,  Ren Xinjun,  Li Xiaorong DOI: 10.3760/cma.j.cn115989-20200307-00150 Published 2021-09-10 Cite asChin J Exp Ophthalmol, 2021, 39(9): 803-810. Abstract Objective To investigate the risk factors of postoperative vitreous hemorrhage (PVH) after vitrectomy for proliferative diabetic retinopathy (PDR). Methods A case-control study was conducted.A total of 1 848 consecutive PDR patients (1 848 […]

Genotypic and phenotypic analysis of RHO gene variants in a Chinese Han autosomal dominant retinitis pigmentosa family

Authors: Zhang Yuwei,  Lou Guiyu,  Yang Ke,  Yang Lin,  Zhu Qing,  Lei Bo DOI: 10.3760/cma.j.cn115989-20201217-00848 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 708-713. Abstract Objective To analyze the pathogenic genes and clinical phenotypes of a Chinese Han family with autosomal dominant retinitis pigmentosa (ADRP). Methods A pedigree investigation study was conducted, and a […]

Genetic testing and clinical phenotypic analysis of familial vitreous amyloidosis in two Han Chinese families

Authors: Zheng Wei,  Li Haibo,  Zhang Xueyong,  Zhou Xuezhi,  Chen Yuanyuan,  Mao Junfeng DOI: 10.3760/cma.j.cn115989-20190721-00318 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 714-718. Abstract Objective To investigate the clinical characteristics of two Han families with familial vitreous amyloidosis (FVA) and the gene mutation. Methods A pedigree investigation was performed.Two Han Chinese families with […]

Clinical characteristics and genetic mutation analysis in a family with familial vitreous amyloidosis

Authors: Yu Qiang,  Huang Xing,  Yang Zhumin,  Wang Xian DOI: 10.3760/cma.j.cn115989-20190923-00412 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 719-723. Abstract Objective To analyze the clinical characteristics and transthyretin (TTR) gene mutation of a family with familial vitreous amyloidosis (FVA). Methods A pedigree investigation was performed.The clinical data of 20 family members of a […]

Efficacy evaluation of intravitreal injection of rAAV2-ND4 gene for Leber hereditary optic neuropathy

Authors: Li Xin,  Tian Zhen,  Chen Zhang,  Li Bin,  Zhang Yong DOI: 10.3760/cma.j.cn115989-20210330-00218 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 724-728. Abstract Objective To evaluate the safety and clinical effect of gene therapy for Leber hereditary optic neuropathy (LHON). Methods A multi-center prospective non-randomized controlled trial was conducted.Eighty eyes of 40 LHON patients […]

Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration: a Meta-analysis

Authors: Gu Hong,  Xu Zhangxing,  Shen Zhaomeng,  Li Zhiguo DOI: 10.3760/cma.j.cn115989-20191117-00498 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 729-736. Abstract Objective To systematically evaluate the association between the hepatic lipase (LIPC) gene rs10468017 polymorphism and susceptibility to age-related macular degeneration (AMD). Methods A systematic search was performed in both English databases (PubMed, Embase, […]

Peripheral retinal fluorescence features of ultra-wide fundus fluorescein angiography in normal fundus eyes

Authors: Wang Xiaoling,  Chen Changzheng,  Xu Amin,  Yi Zuohuizi,  He Lu,  Liu Juejun,  Zheng Hongmei DOI: 10.3760/cma.j.cn115989-20190426-00201 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 609-613. Abstract Objective To analyze the peripheral retinal fluorescence characteristics of normal fundus on ultra-wide field fluorescein angiography (UWFA) images. Methods A cross-sectional study was conducted.Ninety-five patients (190 eyes) […]

Optical coherence tomography angiography of macula in retinopathy of prematurity children with single treatment history

Authors: Zhao Xinyu,  Wu Zhenquan,  Zhang Guoming DOI: 10.3760/cma.j.cn115989-20201104-00740 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 614-618. Abstract Objective To observe the changes of macular morphology and best corrected visual acuity (BCVA) in children with retinopathy of prematurity (ROP) after single treatment of laser photocoagulation or intravitreal injection of ranibizumab (IVR) by optical […]