Advances of ocular surface drug delivery system

Authors: Chen Xiang,  Xu Wen

DOI: 10.3760/cma.j.cn115989-20200123-00038 Published 2020-12-10
Cite as Chin J Exp Ophthalmol, 2020,38(12): 1091-1096.

Abstract

Due to the anatomical and physical barriers, the low bioavailability of eye drops has become the primary problem in optimizing efficacy.Drug delivery system can reduce administration frequency and keep the therapeutic concentration while increasing ocular surface retention time and strengthening ability to permeate the cornea.Therefore, many ophthalmologists and relevant scientists focus on the ocular surface drug delivery system to overcome the drawback of low bioavailability.The advances of drug delivery system in ocular surface in the past decade were reviewed to give an introduction about the advantages and disadvantages as well as advances of nano-constructions, cyclodextrin and its derivatives, gels and contact lens.It is expected that ocular surface drug delivery systems could enhance the bioavailability to some extent, and have a good prospect in clinical practice when existing problems handled.

Key words:

Drug delivery system; Bioavailability; Ocular surface       

Contributor Information

Chen Xiang
Department of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Xu Wen
Department of Ophthalmology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Updated: December 18, 2020 — 6:57 am