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Neovascular glaucoma (NVG) is a dreadful pathology and it will be rapid spontaneous evolution responsible for eventual visual loss in many cases, with poor therapeutic efficiency.The main challenges in clinical practice for the management of NVG are as follows: (1)What is the goal of NVG treatment, to decrease intraocular pressure (IOP) or to reserve visual function? (2)How to create an optimal condition or timing for the treatment of primary disease? (3)What is exactly the key of NVG treatment? Anti-vascular endothelial growth factor (VEGF) medication, anti-glaucoma surgery or pan-retinal photocoagulation (PRP) for strict control of clinical situations potentially responsible for retinal ischemia ? (4)How to set up a comprehensive management strategy for NVG? In this paper, we established a comprehensive treatment strategy for NVG, including a core aim for preserving visual function, a goal of completing PRP and the main methods of anti-VEGF injection and anti-glaucoma surgery in order to preserve visual status of NVG patients as much as possible.