Current researches of function and mechanism of peroxisome proliferator-activated receptor-γ in diabetic retinopathy

Authors: Li Tao,  Zou Haidong

DOI: 10.3760/cma.j.issn.2095-0160.2017.07.016
Published 2017-07-10
Cite as Chin J Exp Ophthalmol, 2017,35(07): 651-654.

Abstract

Peroxisome proliferator-activated receptor gamma (PPAR-γ), a member of the nuclear receptor superfamily, plays a great role in delaying or even preventing the occurrence and/or development of diabetic retinopathy (DR), a complicated out-of-control waterfall-like pathophysiological processes.DR is characterized by pathways, such as inflammatory reactions, the generation of advanced glycation end products, oxidative stress, protein kinase C and so on.As one of the most important metabolic homeostasis and adipocyte differentiation regulator, the single nucleotide polymorphism and molecular structure of PPAR-γ have been proven to impact on anti-inflammation, anti-neovascularization and fibration, antioxidation, insulin sensitizer and anti-apoptosis in DR.This review provided a summary of the function and mechanism researches on PPAR-γ and offered new ideas of prevention and therapy in DR.

Key words:

Peroxisome proliferator-activated receptor-γ; Diabetic retinopathy; Function; Mechanism

Contributor Information

Li Tao
Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
Zou Haidong
Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai 200040, China
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