The function and potential mechanism of the Wnt signaling pathway in retina development and retinal diseases

Authors: Yang Jing,  Li Xiaorong,  Zhang Xiaomin

DOI: 10.3760/cma.j.issn.2095-0160.2019.02.014
Published 2019-02-10
Cite as Chin J Exp Ophthalmol, 2019,37(2): 144-148.

Abstract

Wnt signaling pathway plays a key role in regulating embryonic development and organism growth, which maintains normal physiological function of many tissues and organs.A variety of diseases involve the abnormal activation or inhibition of Wnt signaling pathway.At the stage of retinal development, Wnt signaling pathway is implicated in regulating the formation of retinal field, the maintenance of retinal lamination and the sustentation of retinal stem cell properties, moreover, it is closely related to the development of retinal vessels.Wnt signaling pathway is associated with the development and progression of some retinal diseases, such as familial exudative vitreoretinopathy, age-related macular degeneration, retinoblastoma and diabetic retinopathy.The function and potential mechanism of the Wnt signaling pathway in retina development and retinal diseases were summarized in this review.

Key words:

Wnt signaling pathway; Retina; Development; Retinal diseases

Contributor Information

Yang Jing
Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Tianjin 300384, China
Li Xiaorong
Zhang Xiaomin
(Read 56 times, 1 visits today)
Updated: September 4, 2019 — 5:57 am