Authors: Yang Jing, Li Xiaorong, Zhang Xiaomin
Abstract [Download PDF] [Read Full Text]
Wnt signaling pathway plays a key role in regulating embryonic development and organism growth, which maintains normal physiological function of many tissues and organs.A variety of diseases involve the abnormal activation or inhibition of Wnt signaling pathway.At the stage of retinal development, Wnt signaling pathway is implicated in regulating the formation of retinal field, the maintenance of retinal lamination and the sustentation of retinal stem cell properties, moreover, it is closely related to the development of retinal vessels.Wnt signaling pathway is associated with the development and progression of some retinal diseases, such as familial exudative vitreoretinopathy, age-related macular degeneration, retinoblastoma and diabetic retinopathy.The function and potential mechanism of the Wnt signaling pathway in retina development and retinal diseases were summarized in this review.