Research on simple limbal epithelial transplantation and its application prospects

Damage to limbal due to injury or disease can lead to limbal stem cell deficiency (LSCD).Severe LSCD is difficult to diagnose and treat clinically, while limbal stem cell transplantation (LSCT) is the main treatment.Simple limbal epithelial transplantation (SLET) is a novel technique for LSCT.The procedure involves removing the fibrovascular pannus from the recipient eye, cutting the limbal tissue from the donor eye into tiny pieces, transplanting the epithelial side up onto the corneal surface of the recipient eye, and using amniotic membrane as a carrier to repair the ocular surface.Regular follow-up shows that the corneal epithelialization is completed at approximately two weeks postoperatively through the continuous expansion and migration of the tissue.Compared with other LSCT procedures, SLET is simple to perform, requires less biopsy, and has good repeatability.In addition, SLET has shown good clinical prospects.This article reviews the research progress of SLET.

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