Category: Highlights

Pay attention to the risk of infection and tumor progression during application of TNF-α inhibitors in uveitis

Authors: Chi Ying,  Yang Liu DOI: 10.3760/cma.j.cn115989-20211020-00571 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 929-932. Abstract Adalimumab, one of the tumor necrosis factor-α (TNF-α) inhibitors, has been approved as a therapeutic drug for non-infectious intermediate, posterior and pan-uveitis by FDA.Due to the good efficacy, TNF-α inhibitors are being applied widely in ophthalmology.However, some […]

Enhanced effect of microRNA-338-3p in bone marrow-derived dendritic cells on IRBP1-20-specific T helper 17 cells activation in experimental autoimmune uveitis

Authors: Yang Chao,  Wei Yankai,  Wei Ruihua,  Nian Hong DOI: 10.3760/cma.j.cn115989-20200608-00404 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 933-939. Abstract Objective To investigate the role of microRNA-338-3p (miR-338-3p) in regulating the generation and function of interphotoreceptor retinoid-binding protein (IRBP)1-20-specific T helper 17 (Th17) cells in experimental autoimmune uveitis (EAU). Methods Bone marrow cells […]

Inhibitory effect of rosmarinic acid on high glucose-induced angiogenesis of human retinal microvascular endothelial cells and the activation of NLRP3 inflammasome pathway

Authors: Fan Jiangli,  Guan Yanling,  Li Rong,  Yao Yang DOI: 10.3760/cma.j.cn115989-20191203-00520 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 940-948. Abstract Objective To investigate the inhibitory effects of rosmarinic acid (RA) on high glucose-induced angiogenesis of human retinal microvascular endothelial cells (HRMEC) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway-related proteins. Methods […]

Effects of intravenous injection of human umbilical cord mesenchymal stem cells-derived small extracellular vesicles on experimental autoimmune uveitis in mice

Authors: Li Yongtao,  Duan Yanan,  Li Huan,  Zhang Zhihui,  Ren Xinjun,  Li Xiaorong,  Zhang Xiaomin DOI: 10.3760/cma.j.cn115989-20200430-00302 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 949-956. Abstract Objective To explore the therapeutic effects of intravenous injection of small extracellular vesicles (sEVs) derived from human umbilical cord mesenchymal stem cells (MSCs) on experimental autoimmune uveitis […]

Comparison of the effects of different intraocular infusion solutions on histology and function of retina

Authors: Zhu Li,  Miao Heng,  Hu Qinrui,  Liu Zhiming,  Bai Yujing,  Yu Youzhi,  Fu Yafei,  Xia Huika,  Huang Lvzhen,  Qi Yun,  Deng Xun,  Li Yan,  Li Xiaoxin DOI: 10.3760/cma.j.cn115989-20200810-00575 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 957-967. Abstract Objective To compare the effects of different intraocular infusion solutions on histology and function of […]

Evaluation of corneal nerve damage in diabetic patients after panretinal photocoagulation based on the wide-field mosaic analysis of corneal subbasal nerve plexus

Authors: Huang Shulan,  Zhao Shaozhen,  Wang Xiaowu,  Yang Jizhong,  Zheng Xiaofen,  Han Yuping,  Zhao Juwei,  Hou Guangping,  Yu Hua DOI: 10.3760/cma.j.cn115989-20200615-00436 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 968-974. Abstract Objective To explore the damage of panretinal photocoagulation (PRP) to the subbasal nerve plexus (SNP) and its related mechanisms by comparing SNP changes […]

Comparison of therapeutic effect for diabetic macular edema based on different optical coherence tomography patterns

Authors: Xu Xinyu,  Xia Ying,  Hu Tianming,  Wei Wei DOI: 10.3760/cma.j.cn115989-20190606-00247 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 975-981. Abstract Objective To evaluate the efficacy of intravitreal ranibizumab (IVR) injection and/or laser photocoagulation on diabetic macular edema (DME) of different morphologic patterns based on optical coherence tomography (OCT). Methods A non-randomized controlled clinical […]

Comparison of the protective effect of corneal protectant and balanced salt solution on the ocular surface during minimally invasive vitreous surgery for proliferative diabetic retinopathy

Authors: Wang Wei,  Li Suyan,  Zhang Zhengpei,  Liu Haiyang,  Ji Sujuan DOI: 10.3760/cma.j.cn115989-20200430-00303 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 982-988. Abstract Objective To compare the protective effect of corneal protectant hydroxypropyl methylcellulose (HPMC) and balanced salt solution (BSS) on corneal epithelium in vitreous body surgery for proliferative diabetic retinopathy (PDR). Methods A […]

Multimodal imaging analysis of congenital optic disc pit

Authors: Qiao Xinrui,  Zhou Nalei,  Ma Jingxue,  Shi Junfang,  Dai Li,  Liu Ying,  Li Yihang,  Shi Jinxin,  An Jianbin DOI: 10.3760/cma.j.cn115989-20200721-00517 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 989-996. Abstract Objective To analyze the characteristics of eyes with congenital optic disc pits (ODPs) through multimodal imaging. Methods A cross-sectional study was conducted.Thirty-eight patients […]

Characteristics of multicolor imaging in the acute central serous chorioretinopathy

Authors: He Lu,  Chen Changzheng,  Yi Zuohuizi,  Wang Xiaoling,  Xu Amin,  Liu Juejun DOI: 10.3760/cma.j.cn115989-20210922-00529 Published 2021-11-10 Cite asChin J Exp Ophthalmol, 2021, 39(11): 997-1002. Abstract Objective To investigate the features of multicolor imaging in the macular region of central serous chorioretinopathy (CSC) patients. Methods A cross-sectional study was conducted.Thirty-four acute CSC patients (34 eyes) […]