Authors:Expert Workgroup of Expert consensus on the specification and operation of optical coherence tomography/optical coherence tomography angiography examination in experimental animals (2026), Ophthalmic Imaging and Intelligent Medicine Branch of Chinese Medicine Education Association, Ophthalmology Committee of International Association of Translational Medicine, Ophthalmology Committee of International Association of Intelligent Medicine, Chinese Ophthalmic Imaging Study Group Corresponding […]
Category: Highlights
Accuracy and repeatability of fluorescence PCR for detecting TGFBI gene mutation in corneal dystrophy
Authors:Sun Xiuli, Gu Yixuan, Zhu Lei,Tian Lei, Wang Yinghui,Jie Ying Corresponding author:Jie Ying, Email:jie_yingcn@aliyun.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250916-00300 ABSTRACT Objective To evaluate the accuracy and repeatability of fluorescence PCR in detecting TGFBI gene mutation in patients with corneal dystrophy. Methods ARMS-PCR combined with TaqMan probe method was used for genotyping the R124H, R124C, R555W, and R555Q loci (covering heterozygous and homozygous mutation) in the TGFBI gene in peripheral […]
Effect and mechanism of haptoglobin regulating retinal vascular barrier and mediating inflammatory response in diabetic macular edema
Authors:Zhang Yue, Li Jiayu, Zhai Xinran, Yao Yao, Li Liyan, Xiao Zhe, Chen Han, Pang Wu, Yang Zanzhang, Zhang Minglian Corresponding author:Zhang Minglian, Email:zhmlyk@163.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250521-00166 ABSTRACT Objective To investigate the role and mechanism of haptoglobin (HP) in regulating retinal vascular barrier function and inflammatory response in diabetic macular edema (DME). Methods Aqueous humor samples were collected from 7 patients with non-proliferative diabetic retinopathy (NPDR) and […]
Clinical characteristics and genotype of a family with Waardenburg syndrome type Ⅰ
Authors:Gu Liang, Gao Fengjie, Guan Huaijin, Ji Min Corresponding author:Ji Min, Email:amyji1234@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250303-00063 ABSTRACT Objective To analyze the clinical and genetic characteristics of a family with Waardenburg syndrome type Ⅰ (WS1) . Methods A pedigree investigation was conducted. Clinical data from 3 generations of 7 people from a family with WS1 in the Nantong area of China, Jiangsu Province, […]
Comparison of 0.5% tropicamide versus 1% tropicamide in cycloplegic optometry in myopic Chinese children: a randomized controlled clinical trial
Authors:Rong Hua, Zhou Yifan, Du Bei, Chong Liuyun, Cai Zhaoying, Liu Ruoxuan, Yu Jingtao, Wei Ruihua Corresponding author:Wei Ruihua, Email:rwei@tmu.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20241226-00364 ABSTRACT Objective To compare the effects of two dosing regimens, four instillations of 0.5% tropicamide and two instillations of 1% tropicamide, on cycloplegia and ocular biometric parameters in myopic children. Methods A randomized controlled trial was performed. Sixty myopic children (60 eyes) […]
Gene research progress of Fuchs endothelial corneal dystrophy
Authors:Gao Fengjie, Guan Huaijin, Ji Min Corresponding author:Ji Min , Email:amyji1234@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20241113-00309 ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is a bilateral inherited corneal disorder characterized by irreversible degeneration of the corneal endothelium. Clinically, it manifests as a progressive loss of corneal endothelial cells, stromal edema, and gradual deterioration of visual function. In advanced stages, corneal transplantation remains the […]
Research progress of tetrahedral framework nucleic acids in ophthalmology
Authors:Zhang Pengcheng, Wang Liqiang, Liu Anqi Corresponding author: Liu Anqi, Email:liuanqi301@hotmail.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20250411-00114 ABSTRACT In the field of ophthalmology, particularly in tissue regeneration, although gene therapy, stem cells, and drug development are highly regarded, their clinical translation still faces bottlenecks such as easy degradation in vivo, low delivery efficiency, and lack of targeting. In recent years, nucleic acid nanomaterials […]
Retinal structure and function in the rd10 mouse model of retinitis pigmentosa: current status and future perspectives
Authors:Yang Hongli, Zhang Hui, Li Xiaorong Corresponding author: Li Xiaorong, Email:lixiaorong@tmu.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20240303-00061 ABSTRACT Retinitis pigmentosa (RP) is a genetically inherited disorder characterized by the progressive degeneration of photoreceptors and a subsequent decline in visual function. Although various treatments, such as neuroprotective drugs, gene repair or gene therapy, and transplantation of stem cells and their derivatives, have been explored, […]
Research progress on targeted regulation of regulatory T cells in new strategies for dry eye treatment
Authors:Liu Lirui, Xu Wen Corresponding author: Xu Wen, Email:xuwen2003@zju.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20230720-00044 ABSTRACT Dry eye is a multifactorial ocular surface disease characterized by the loss of tear film homeostasis caused by many factors, which is often accompanied by ocular surface discomfort, and the related immune mechanism is involved in its occurrence and development. Regulatory T cells (Tregs) are the […]
Research progress of drug-loaded hydrogel in the treatment of uveitis
Authors:Wang Qimiao, Shan Mengyuan, Wang Yan Corresponding author: Wang Yan, Email:wangyan7143@vip.sina.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20231010-00122 ABSTRACT Uveitis is a potentially blinding ocular inflammatory disease characterized by a prolonged course and a high recurrence rate. The clinical treatment of uveitis is limited by the blood-ocular barrier, which reduces the absorption and bioavailability of topically administered drugs. Frequent administration […]