Category: Highlights

Promoting the research and development of drug for cataract and reducing the blindness rate of cataract

Author: Wang Yandong DOI: 10.3760/cma.j.cn115989-20201102-00726 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1001-1003. Abstract With the aging of the population and changes of people’s lifestyle, age-related eye disease, metabolic-related eye disease and fundus lesions caused by high myopia become the main causes of blindness in China.Up to now, the only therapy for age-related […]

Preparation and drug release effect evaluation of drug-loaded cross-linked decellularized corneal stromal lenticules in vitro

Authors: Rao Jing,  Chen Jiansu,  Gu Jianing,  Chen Xiao,  Wang Yini,  Liu Yonghuan,  Pu Aijun,  Zhou Qizhi DOI: 10.3760/cma.j.cn115989-20190817-00353 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1004-1010. Abstract Objective To prepare a drug release system of drug-loaded cross-linked decellularized corneal stromal lenticules and evaluate its drug release characteristics in vitro. Methods Lenticules were […]

Network pharmacology analysis of metformin against diabetic retinopathy

Authors: Chen Yuan,  Xing Qian,  Huang Zhengru DOI: 10.3760/cma.j.cn115989-20191215-00543 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1011-1015. Abstract Objective To explore the pharmacological molecular mechanisms of metformin against diabetic retinopathy (DR) based on network pharmacology approach. Methods After chemical constitution of metformin was acquired from Pubchem database, target genes of metformin were identified […]

Anti-apoptosis and anti-inflammation effects and mechanism of berberine on high-concentration glucose induced rat retinal Müller cells

Authors: Jin Yiping,  Zhu Haohao,  Liao Yujie,  Yu Xiaoyan DOI: 10.3760/cma.j.cn115989-20200917-00647 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1016-1024. Abstract Objective To investigate the effects of berberine on Sprague Dawley (SD) rat retinal Müller cells cultured by high concentration glucose. Methods The cultured SD rat retinal Müller cells were divided into normal-glucose group, […]

Protective effect and mechanism of esculetin on oxidative damaged ARPE-19 cells

Authors: Zhang Yingjun,  Bai Ge,  He Xiangdong,  Zhang Donglei,  He Wei DOI: 10.3760/cma.j.cn115989-20200224-00101 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1025-1031. Abstract Objective To study the protective effect and the mechanism of esculetin on oxidative-stressed human retinal pigment epithelial cells (ARPE-19) induced by tert-butyl hydroperoxide (t-BHP). Methods The ARPE-19 cells were divided into […]

Ocular pharmacokinetics of econazole solid lipid nanoparticle eye drops after single dose topical administration in rabbits

Authors: Liang Zhen,  Zhang Zhen,  Li Jingguo,  Yang Jingjing,  Lu Ping,  Zhou Tianyang,  Zhang Junjie DOI: 10.3760/cma.j.cn115989-20191008-00429 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1032-1037. Abstract Objective To investigate the pharmacokinetics of econazole solid lipid nanoparticles (E-SLNs) after administration of one single dose in rabbit eyes. Methods E-SLNs with 0.2% econazole was prepared […]

Ocular pharmacokinetics of topical administration of butenafine nanomicelles in rabbit eyes

Authors: Lu Ping,  Liang Zhen,  Zhang Zhen,  Yang Jingjing,  Song Fei,  Li Jingguo,  Zhou Tianyang,  Zhang Junjie DOI: 10.3760/cma.j.cn115989-20200526-00374 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1038-1044. Abstract Objective To study the pharmacokinetics of the broad-spectrum antifungal drug butenafine nanomicelles (BTF-NM) after topical instillation. Methods The self-assembly method was used to prepare BTF-NM.The […]

Influence of benzalkonium chloride in anti-glaucoma medications on intraocular pressure and ocular surface: a Meta-analysis

Authors: Liu Liling,  Wu Kaili,  Yu Minbin DOI: 10.3760/cma.j.cn115989-20200917-00650 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1045-1051. Abstract Objective To evaluate the influence of benzalkonium chloride (BAK) in anti-glaucoma medication on intraocular pressure and ocular surface. Methods A Meta-analysis was performed.The literature about anti-glaucoma medications published in PubMed, EMbase, Cochrane Library from January […]

Effects of recombinant human epidermal growth factor on epithelial recovery and tear film stability after enhanced transepithelial corneal crosslinking

Authors: Lin Zhirong,  Wu Huping,  Luo Shunrong,  Xie Zhiwen,  Fang Xie,  Xiao Xianwen,  Yan Lei,  Dong Nuo,  Shang Xumin,  Liu Zhaosheng DOI: 10.3760/cma.j.cn115989-20200917-00651 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1052-1059. Abstract Objective To investigate the impact of recombinant human epidermal growth factor (rh-EGF) on the epithelial recovery and the tear film stability […]

A randomized controlled clinical study on amniotic stent and silicone tube implantation through nasolacrimal duct for the treatment of lacrimal duct obstruction disease

Authors: Cui Hua,  Xiao Fan,  Lai Pinghong,  He Yalin,  Zhou Min,  Zhao Jialiang DOI: 10.3760/cma.j.cn115989-20190610-00253 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1061-1065. Abstract Objective To investigate the efficacy and side effects of amnion stent implanted in lacrimal duct for the lacrimal duct obstruction diseases (LDOD). Methods A randomized controlled clinical trial was […]