Citation
Wu Jiali, Shao Yi. Fibrin-based therapies in periorbital rejuvenation: mechanisms, clinical techniques, and future perspectives[J]. Chin J Exp Ophthalmol, 2025, 43(9):777-784.
DOI: 10.3760/cma.j.cn115989-20250512-00149.
ABSTRACT [Download PDF] [View Full Text]
As a natural scaffold material with bioactive and biodegradable properties, fibrin demonstrates multidimensional therapeutic advantages in periorbital rejuvenation, including biocompatibility, degradability, and growth factor release kinetics.This article systematically reviews the classification of fibrin and its characteristic differences, with a focus on elucidating its mechanisms of action in periorbital applications, such as structural support and immediate volume filling, biostimulation and tissue regeneration, and immunomodulation of the microenvironment.Significant progress has been made in current clinical techniques regarding fibrin sources and preparation, combination strategies, and efficacy evaluation.Current clinical evidence indicated that fibrin-based monotherapy or combination therapies can significantly improve periorbital fine lines, skin texture, and hollowing, technical challenges remain, including short duration of effect, insufficient mechanical support, and technique-sensitive injection protocols.Further research should focus on material modification and intelligent delivery systems to address these challenges, thereby providing breakthrough solutions for periorbital rejuvenation from transient improvement to long-term regeneration.