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Fungal endophthalmitis is a kind of severe ocular infectious disease with poor prognosis.The damage degree of fungal endophthalmitis to ocular tissues is due to the fungi’s destructivity, delayed diagnosis and non-standardized therapy.Early and proper intervention is crucial for saving visual function.There are different features of risk factors, pathogens and clinical presentations in exogenous infection and endogenous infection.Different key points of theraputic approaches should be identified to achieve early diagnosis and effective treatment, such as reasonably selecting the right type of antifungal drugs, different ways of administration, appropriate drug dose or surgical method.In the treatment of fungal endophthalmitis, the application of glucocorticoid is controversial, and the use of local or systemic glucocorticoid should be avoided as far as possible.