Category: 2019, No. 05

Recent advances in regulatory effects of microRNA in thyroid-associated ophthalmopathy

Authors: Chen Lan,  Li Kaijun DOI: 10.3760/cma.j.issn.2095-0160.2019.05.015 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 396-400. Abstract MicroRNAs (miRNAs) are endogenous, single-stranded, noncoding RNAs with 18 to 24 nucleotides in length.miRNAs play important regulatory roles by targeting mRNAs for cleavage or translational repression.Thus, they negatively regulate gene expression at the post-transcriptional level.miRNA can degrade target […]

Research progress on single nucleotide polymorphisms of genes associated with diabetic retinopathy

Authors: Han Junlin,  Han Mei DOI: 10.3760/cma.j.issn.2095-0160.2019.05.014 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 390-395. Abstract Diabetic retinopathy (DR) is the common cause of irreversible vision loss in adults during working age, accounting for 4.8% of global blindness.With the progress of disease, most patients with diabetes mellitus will eventually lead to DR.Epidemiological studies have […]

Changes in corneal biomechanical properties before and after operation in different types of glaucoma

Authors: Wang Rui,  Yang Jin,  Yin Zelin,  Tian Xiaofeng,  Li Xuan DOI: 10.3760/cma.j.issn.2095-0160.2019.05.013 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 382-389. Cite as Chin J Exp Ophthalmol, 2019,37(5): 342-347. Abstract Objective To compare the differences of corneal biomechanics in different types of glaucoma and its related influence factors, and to investigate the change trends of cornea biomechanics after the […]

Evaluation of photodynamic therapy based on indocyanine green angiography for circumscribed choroidal hemangioma

Authors: Wang Yue,  Li Suyan,  Liu Yalu,  Sun Yongcheng,  Wu Shuang DOI: 10.3760/cma.j.issn.2095-0160.2019.05.012 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 376-381. Abstract Objective To observe the efficacy of photodynamic therapy (PDT) based on indocyanine green angiography (ICGA) for circumscribed choroidal hemangioma (CCH). Methods A retrospective observational case series study was performed.Seventeen eyes of 17 […]

Clinical characteristics of pediatric ocular toxocariasis

Authors: Liu Jinghua,  Li Songfeng,  Deng Guangda,  Li Liang,  Ma Jing,  Ma Yan,  Lu Hai DOI: 10.3760/cma.j.issn.2095-0160.2019.05.011 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 371-375. Abstract Objective To describe the clinical manifestations of pediatric ocular toxocariasis. Methods The clinical data of 163 pediatric patients (163 eyes) with ocular toxocariasis from March 2012 to March […]

Comparative study of intravitreal dexamethasone implant in the treatment of macular edema secondary to central retinal vein occlusion with different ages

Authors: Lu Yingyi,  Gu Xiaoya,  Yu Xiaobing,  Dai Hong DOI: 10.3760/cma.j.issn.2095-0160.2019.05.009 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 363-368. Abstract Objective To compare the efficacy of intravitreal dexamethasone implant (OZURDEX®) in the treatment of macular edema (ME) caused by central retinal vein occlusion (CRVO) in different ages. Methods A retrospective case observation study was performed.Forty eyes of […]

Clinical observation of modified intracystic ethanol irrigation on traumatic iris cyst patients

Authors: Li Haibo,  Yan Hua,  Cai Jinhong,  Huang Yanming,  Wu Duanxiao DOI: 10.3760/cma.j.issn.2095-0160.2019.05.008 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 358-362. Abstract Objective To evaluate the efficacy and safety of modified intracystic ethanol irrigation for traumatic iris cyst eyes. Methods A retrospective analysis was designed.Twelve cases of traumatic iris cyst patients were observed from August 2016 to August 2018 in […]

Construction of lentivirus-mediated mito-OGG1 gene overexpression and OGG1 gene knockdown model in 661W cells

Authors: Li Han,  Ma Wei,  Shi Kangpei,  Wang Lei,  Huang Hao,  Wu Wenbin,  Zhang Xiaotong,  Zhu Xiaobo DOI: 10.3760/cma.j.issn.2095-0160.2019.05.006 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 348-356. Abstract Objective To construct and authenticate the lentiviral-mediated overexpression of mouse mitochondrial-targeted-8-oxoguanine DNA-glycosylase 1 (mito-OGG1) gene and the lentiviral-mediated short hairpin RNA (shRNA) down-regulation of OGG1 gene expression model […]

Inhibitory effect of Tanshinone ⅡA on the proliferation of human retinal pigment epithelial cells in hypoxia and its mechanism

Authors: Lei Xiang,  Li Zhanrong,  Fan Ke DOI: 10.3760/cma.j.issn.2095-0160.2019.05.005 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 342-347. Abstract Objective To investigate the effect of Tanshinone ⅡA on the proliferation and the signaling pathway of human retinal pigment epithelial (RPE) cells in hypoxia. Methods CoCl2 (150 μmol/L) was used to simulate hypoxic condition and the ARPE-19 […]

Effect of adenosine kinase small interfering RNA modified corneal endothelial cells on the proliferation and secretion of regulatory T cells

Authors: Zhang Wanhong,  Jiao Huiying,  Ruan Yanfei,  Liu Yuanzhen Published 2019-05-10 DOI: 10.3760/cma.j.issn.2095-0160.2019.05.004 Cite as Chin J Exp Ophthalmol, 2019,37(5): 337-341. Abstract Objective To investigate the role of adenosine kinase (ADK)small interfering RNA(siRNA) modified corneal endothelial cells on the proliferation and secretion of regulatory T cells (Treg cells). Methods The experiment was divided into transfected group […]