Authors: Chen Lan, Li Kaijun DOI: 10.3760/cma.j.issn.2095-0160.2019.05.015 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 396-400. Abstract MicroRNAs (miRNAs) are endogenous, single-stranded, noncoding RNAs with 18 to 24 nucleotides in length.miRNAs play important regulatory roles by targeting mRNAs for cleavage or translational repression.Thus, they negatively regulate gene expression at the post-transcriptional level.miRNA can degrade target […]
Category: 2019, No. 05
Research progress on single nucleotide polymorphisms of genes associated with diabetic retinopathy
Authors: Han Junlin, Han Mei DOI: 10.3760/cma.j.issn.2095-0160.2019.05.014 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 390-395. Abstract Diabetic retinopathy (DR) is the common cause of irreversible vision loss in adults during working age, accounting for 4.8% of global blindness.With the progress of disease, most patients with diabetes mellitus will eventually lead to DR.Epidemiological studies have […]
Changes in corneal biomechanical properties before and after operation in different types of glaucoma
Authors: Wang Rui, Yang Jin, Yin Zelin, Tian Xiaofeng, Li Xuan DOI: 10.3760/cma.j.issn.2095-0160.2019.05.013 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 382-389. Cite as Chin J Exp Ophthalmol, 2019,37(5): 342-347. Abstract Objective To compare the differences of corneal biomechanics in different types of glaucoma and its related influence factors, and to investigate the change trends of cornea biomechanics after the […]
Evaluation of photodynamic therapy based on indocyanine green angiography for circumscribed choroidal hemangioma
Authors: Wang Yue, Li Suyan, Liu Yalu, Sun Yongcheng, Wu Shuang DOI: 10.3760/cma.j.issn.2095-0160.2019.05.012 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 376-381. Abstract Objective To observe the efficacy of photodynamic therapy (PDT) based on indocyanine green angiography (ICGA) for circumscribed choroidal hemangioma (CCH). Methods A retrospective observational case series study was performed.Seventeen eyes of 17 […]
Clinical characteristics of pediatric ocular toxocariasis
Authors: Liu Jinghua, Li Songfeng, Deng Guangda, Li Liang, Ma Jing, Ma Yan, Lu Hai DOI: 10.3760/cma.j.issn.2095-0160.2019.05.011 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 371-375. Abstract Objective To describe the clinical manifestations of pediatric ocular toxocariasis. Methods The clinical data of 163 pediatric patients (163 eyes) with ocular toxocariasis from March 2012 to March […]
Comparative study of intravitreal dexamethasone implant in the treatment of macular edema secondary to central retinal vein occlusion with different ages
Authors: Lu Yingyi, Gu Xiaoya, Yu Xiaobing, Dai Hong DOI: 10.3760/cma.j.issn.2095-0160.2019.05.009 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 363-368. Abstract Objective To compare the efficacy of intravitreal dexamethasone implant (OZURDEX®) in the treatment of macular edema (ME) caused by central retinal vein occlusion (CRVO) in different ages. Methods A retrospective case observation study was performed.Forty eyes of […]
Clinical observation of modified intracystic ethanol irrigation on traumatic iris cyst patients
Authors: Li Haibo, Yan Hua, Cai Jinhong, Huang Yanming, Wu Duanxiao DOI: 10.3760/cma.j.issn.2095-0160.2019.05.008 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 358-362. Abstract Objective To evaluate the efficacy and safety of modified intracystic ethanol irrigation for traumatic iris cyst eyes. Methods A retrospective analysis was designed.Twelve cases of traumatic iris cyst patients were observed from August 2016 to August 2018 in […]
Construction of lentivirus-mediated mito-OGG1 gene overexpression and OGG1 gene knockdown model in 661W cells
Authors: Li Han, Ma Wei, Shi Kangpei, Wang Lei, Huang Hao, Wu Wenbin, Zhang Xiaotong, Zhu Xiaobo DOI: 10.3760/cma.j.issn.2095-0160.2019.05.006 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 348-356. Abstract Objective To construct and authenticate the lentiviral-mediated overexpression of mouse mitochondrial-targeted-8-oxoguanine DNA-glycosylase 1 (mito-OGG1) gene and the lentiviral-mediated short hairpin RNA (shRNA) down-regulation of OGG1 gene expression model […]
Inhibitory effect of Tanshinone ⅡA on the proliferation of human retinal pigment epithelial cells in hypoxia and its mechanism
Authors: Lei Xiang, Li Zhanrong, Fan Ke DOI: 10.3760/cma.j.issn.2095-0160.2019.05.005 Published 2019-05-10 Cite as Chin J Exp Ophthalmol, 2019,37(5): 342-347. Abstract Objective To investigate the effect of Tanshinone ⅡA on the proliferation and the signaling pathway of human retinal pigment epithelial (RPE) cells in hypoxia. Methods CoCl2 (150 μmol/L) was used to simulate hypoxic condition and the ARPE-19 […]
Effect of adenosine kinase small interfering RNA modified corneal endothelial cells on the proliferation and secretion of regulatory T cells
Authors: Zhang Wanhong, Jiao Huiying, Ruan Yanfei, Liu Yuanzhen Published 2019-05-10 DOI: 10.3760/cma.j.issn.2095-0160.2019.05.004 Cite as Chin J Exp Ophthalmol, 2019,37(5): 337-341. Abstract Objective To investigate the role of adenosine kinase (ADK)small interfering RNA(siRNA) modified corneal endothelial cells on the proliferation and secretion of regulatory T cells (Treg cells). Methods The experiment was divided into transfected group […]