Aspirin and the formation of eye neovascularization

Aspirin is one of the most important non-steroidal anti-inflammatory drugs, could inhibit cyclooxygenase.It has the antipyretic-analgesic, anti-inflammatory and anti-platelet effects, and has been widely used in preventing heart cerebrovascular disease and rheumatic autoimmune disease.Neovascularization is a self-healing mechanism.However, it also plays the role of the destroyer in cancer and eye diseases at the same time.The pathology of aspirin in the generation of neovascularization, is still in the stage of a fierce debate.On one hand, aspirin has a certain inhibitory effect to the vascular endothelial growth factor (VEGF), which is the strongest factor in neovascularization.On the other hand, aspirin also has the strongest inhibitory effect to endostatin, which is a kind of anti-neovascularization factor.That may lead to the producing of VEGF.Moreover, aspirin may destroy the blood retinal barrier (BRB), which can also cause the formation of retinal neovascularization in a way.Meanwhile, we analyzed the role of aspirin in diseases which can form the neovascular.In the future study, the relationship between aspirin and neovascularization of eye will be further studied.We must measure the pros and cons in the prevention and control of neovascularization when using aspirin.

Aspirin; Choroidal neovascularization; Blood-retinal barrier; Endostatin; Vascular endothelial growth factor