Role of cysteine-rich protein 61 in ocular neovascular disease

Cysteine-rich protein 61 (CYR61) is a secreted protein.It consists of four different structural domains and plays an important role in all kinds of cell life activities, such as proliferation, migration, adhesion, angiogenesis, inflammation regulation, embryogenesis and cartilage formation, by the means of controlling variety of cytokines and signaling pathways.Meanwhile, it also has been widely concerned because of its critical function in neovascularization.In this paper, we present the research progress in CYR61 and its application in ocular fundus neovascular disease, such as diabetic retinopathy, retinopathy of prematurity and wet age-related macular degeneration, in the structure of review, so as to provide a new perspective on the pathogenesis and therapy of ocular fundus neovascular disease.