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Maintaining normal aqueous humor outflow (AHO) is important for intraocular cellular health and vision stabilization.AHO impairment may lead to increased intraocular pressure, optic nerve damage, and concomitant glaucoma.A heightend understanding of AHO will help to improve the glaucoma surgeries that enhance native AHO and will facilitate the development of AHO-targeted pharmaceuticals.Aqueous angiography of AHO is an anterior segment angiography technique similar to fundus fluorescein angiography.It uses fluorescein or indocyanine green to assist AHO, but the trajectory of the aqueous humor is imaged, rather than the movement of blood flow.The contrast agent is introduced into the anterior chamber, and its trajectory is tracked through the aqueous humor cycle to capture 360° aqueous effluent outflow information around the limbus and obtain real-time and dynamic AHO image data.The researchers studied the AHO characteristics of different species of isolated eyeballs and observed the dynamic changes of AHO in non-human primates.Based on this, the trajectory and characteristics of the drainage of live human aqueous humor were further studied.Aqueous humor angiography, as a new tool for AHO functional assessment, has brought new research to AHO functions.However, as it is an invasive examination method, there are many limiting factors in the research process.To better understand the technology, this article reviews the emergence, progress, and current status of aqueous angiography.