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Facial autologous fat filling is widely accepted as a kind of facial cosmetic surgery.However, the postoperative complications, such as periorbital firm mass, ptosis and palpebral erythema, affect appearance and health seriously after surgery.Periorbital lipogranuloma is an ophthalmic complication of facial autologous fat filling which may be due to the nonviable adipocytes.The location of periorbital lipogranuloma is directly associated with fat filling site.The present therapies for periorbital lipogranuloma include the application of glucocorticoid and surgery.Most ophthalmologists in China know little about this disease, leading to misdiagnosis and overtreatment in clinical practice.This review summarizes the clinical characteristics of periorbital lipogranuloma in order to provide guidance for clinical diagnosis and treatment.