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Monocyte chemoattractant protein-1 (MCP-1) polymorphisms are demonstrated to be significantly associated with the susceptibility to uveitis in recent years, while a consistent conclusion for the association of MCP-1-2518A/G polymorphism and uveitis risk is not reached yet.
This study was to comprehensively investigate the correlation between MCP-1-2518A/G polymorphism and uveitis susceptibility.
General searches of electronic database including PubMed, Embase, Web of Science, CNKI, VIP, Wanfang database and China biomedical literature database (CBD) were performed to retrieve published case-control studies regarding the association between MCP-1 -2518A/G polymorphism and uveitis risk. The data were screened according to the inclusion and exclusion criteria and extracted, and the quality of included studies was evaluated. The pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Publication bias and sensitivity analysis were also assessed. All statistical analyses were conducted with RevMan 5. 2 and Stata 12. 0 software.
A total of 8 eligible case-control studies involving 1 197 cases and 1 570 controls were included in the Meta-analysis. The results showed no significant association of MCP-1 -2518A/G polymorphism with uveitis susceptibility in the G vs. A, GG vs. AA and GG vs. AG+ AA models (all at P>0. 05). MCP-1 -2518A/G polymorphism was found to be significantly associated with uveitis risk in the GG+ AG vs. AA model (P=0. 01, OR=1. 25, 95%CI: 1. 06-1. 48), while no significant association was found by the sensitive analysis(GG+ AG vs. AA: P=0. 19, OR=1. 16, 95%CI: 0. 93-1. 45). The subgroup analysis by uveitis types revealed that the individuals carrying allele-G or GG genotype harbored a significantly increased risk for anterior uveitis (G vs. A: P=0. 01, OR=1. 49, 95%CI: 1. 16-1. 90; GG vs. AA: P=0. 01, OR=2. 09, 95%CI: 1. 21-3. 61; GG+ AG vs. AA: P=0. 01, OR=1. 58, 95%CI: 1. 12-2. 23; GG vs. AG+ AA: P=0. 01, OR=1. 78, 95%CI: 1. 12-2. 83). The individuals with GG+ AG vs. AA genotype harbored a significantly increased risk for Behcet’s disease (BD) (P=0. 04, OR=1. 35, 95%CI: 1. 01-1. 79) but not for other types of uveitis (P>0. 05). Additionally, a significantly elevated risk was found in uveitis patients with allele-G or GG genotype in Asian population in the subgroup analysis based on ethnicity (G vs. A: P=0. 04, OR=1. 15, 95%CI: 1. 01-1. 32; GG vs. AA: P=0. 04, OR=1. 32, 95%CI: 1. 02-1. 71; GG+ AG vs. AA: P=0. 01, OR=1. 36, 95%CI: 1. 09-1. 70), but that was not found in Caucasians population (all at P>0. 05).
MCP-1 -2518A/G polymorphism is significantly associated with the risk of uveitis in Asian population, anterior uveitis and BD. The allele-G or GG genotype may increase the risk of uveitis in Asian population, anterior uveitis and BD.