A pilot study on photoreceptor IS/OS and subfoveal choroidal thickness in IMH with spectral domain OCT

Authors: Xiao Zefeng,  Luo Na,  Li Fabiao,  Qiu Zhiqiao,  Yan Shigang
DOI: 10.3760/cma.j.issn.2095-0160.2015.11.012
Published 2015-11-10
Cite as Chin J Exp Ophthalmol, 2015,33(11): 1019-1022.

Abstract                              [Download PDF] [Read Full Text]


The classical theory from Gass holds that idiopathic macular hole (IMH) is due to the dragging of vitreous cortex in the tangent direction on the macular region, while spectral domain OCT (SD-OCT) studies found that the diameters of inner segment/outer segment(IS/OS) absence (DIOA) region was closely associated with vision ability of IMH patients.Enhanced depth imaging (EDI) is thought to be a new method to study the relation between DIOA and subfoveal choroidal thickness (SFCT), but there are few relevant reports.


This study aimed to observe the correlation between photoreceptor IS/OS junction and SFCT before and after vitrectomy in IMH by EDI SD-OCT.


Forty unilateral IMH patients were enrolled in Affiliated Foshan Hospital of Southern Medical University from June 2011 to June 2013.Vitrectomy (23G) was performed on the patients by the same operator.EDI mode of SD-OCT was used to measure DIOA and SFCT in horizontal direction before and 6 months after surgery.The relationship between DIOA and SFCT was evaluated using Pearson linear correlation analysis.Written informed consent was obtained from each patient before medical assessment.


IMH was anatomically closed after vitrectomy in 34 eyes with the closure rate 85%.The mean DIOA was (1 280±753)μm in preoperation, which was significantly higher than (656±322)μm in postoperation (t=4.989, P=0.000). The mean SFCT was (130±43)μm in preoperation, showing a slight reduce in comparison with (140±38)μm in postoperation, but there was not statistical significance between them (t=-1.407, P=0.175). Negative correlations were found between DIOA and SFCT in both preoperation and postoperation (preoperation: r=-0.748, P=0.000; postoperation: r=-0.686, P=0.001).


The alteration of DIOA shows a negative correlation with SFCT in IMH eyes, suggesting a contributing role of the choroid in the change of photoreceptors of IMH.

Key words:

Tomography, optical coherence; Retinal perforations/physiopathology; Fovea centralis; Idiopathic macular hole; Photoreceptor; Choroidal thickness

Contributor Information

Xiao Zefeng
Eye Centre, Affiliated Foshan Hospital of Southern Medical University, Foshan 528000, China
Luo Na
Li Fabiao
Qiu Zhiqiao
Yan Shigang
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Updated: February 28, 2023 — 9:10 am