A randomized controlled clinical trial of the effectiveness and safety between aspherical and NUV soft hydrophilic contact lenses for myopia patients

Authors: Wang Hongge,  Wan Xia,  Wang Yaling,  Sun Xuehua,  Lan Xiaoyan,  Zhang Jie
DOI: 10.3760/cma.j.issn.2095-0160.2015.06.012
Published 2015-06-10
Cite as Chin J Exp Ophthalmol, 2015,33(6): 537-540.

Abstract                              [Download PDF] [Read Full Text]

Background

The clinical effectiveness of soft corneal contact lens for correction of myopia has been confirmed.Theoretically, aspherical soft hydrophilic corneal contact lens has better visual qualify for myopic eyes, and the lenses have been applied widely.But abnormal tear film, even many cornea and conjuctiva diseases caused by soft contact lens have been reported, so the effectiveness and safety of aspherical soft hydrophilic corneal contact lens are worth concerning.

Objective

This clinical trail was to compare the effectiveness and safety between aspherical and NUV soft hydrophilic contact lens for myopic eyes.

Methods

A randomized, double-blind and controlled clinical study was performed under the approval of Ethic Committee of Qingdao Municipal Hospital and informed consent of each patient.One hundred and forty eyes of 70 myopic patients were enrolled in Qingdao Municipal Hospital from July to October, 2012.The subjects were randomized into the trial group and control group using random number table.Aspherical soft hydrophilic contact lenses were worn in the trial group and NUV soft hydrophilic contact lenses were worn in the control group.The characteristics of the lens surface, outcomes and the eye number in different scores of ocular signs and symptoms were assessed before and 15 minutes, 1 week, 2 weeks and 1 month after wearing lenses.

Results

The sores of humidity of anterior surface, the sediment in anterior and posterior surface are 0 in both lenses in various time points after wearing.The corrected visual acuity of all the subjects were ≥1.0.The eye number of 2-3 scores in various ocular signs was 0 in both groups, but the eye number of 1 score in palpebral conjunctival congestion and limbus congestion were more in the trail group than those in the control group in different time points (all at P<0.05). There were significant differences in corneal fluorescine staining between the groups in different time points (all at P>0.05). There was no eye for 2-3 scores of eye symptoms in both groups.The eye number for 1 score in foreign body sensation increased in the target-trail group compared to the control group at various time points (P=0.002, 0.006, 0.005, 0.005). However, there was no statistically significant differences in the eye number for 1 score in visual clearness and stability between the two groups at the follow-up duration (all at P>0.05).

Conclusions

Aspherical soft hydrophilic corneal contact lens has good outcomes in corrected visual acuity for myopia like NUV soft hydrophilic contact lens, but the wearing of aspherical soft hydrophilic corneal contact lens induces more ocular discomfortableness.

Key words:

Contact lenses, hydrophilic/adverse effects; Myopia; Aspherical lens; Effectiveness; Safety; Randomized controlled clinical trail

Contributor Information

Wang Hongge
Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao 266011, China
Wan Xia
Wang Yaling
Sun Xuehua
Lan Xiaoyan
Zhang Jie
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Updated: March 31, 2023 — 7:21 am