After disinfection, the eye speculum was placed and Oxybuprocaine Hydrochloride Eye Drops was applied in the operative eye, and the cornea was soaked with 18% ethanol for 20 seconds. When the corneal epithelium was loosened, the epithelial tissue within central 10 mm diameter of the cornea was removed. The 0.1% riboflavin eye drops was administered every 90 seconds, for a total of 10 minutes. Whether riboflavin had penetrated the whole corneal stroma and entered the aqueous humor of the anterior chamber was determine under a cobalt blue filter on the slit lamp microscope. The KXL® system, Avedro’s corneal cross-linking procedure was utilized to irradiate the cornea at a wavelength of 370 nm, and an intensity of 30 mW/cm2, for 4 minutes. Artificial tear drops were used in the process of irradiation to maintain corneal surface humidity.
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