Animal models of oxygen-induced retinopathy

Authors: Yang Ning,  Xing Yiqiao

DOI: 10.3760/cma.j.issn.2095-0160.2018.01.013
Published 2018-01-10
Cite as Chin J Exp Ophthalmol, 2018,36(1): 61-64.

Abstract

Models of oxygen-induced retinopathy (OIR) have been built on several animals, including kitten, mouse, rat, rabbit, puppy and zebrafish.These models play an important role in studying the mechanisms and treatments of retinal neovascularization, which is partially mimicking the pathological process of retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). As the extensive application of transgenic technology, animal models of OIR will provide more evidences on investigating the retinal angiogenic diseases.However, none of these OIR models is perfect to simulate human ROP completely, which still needs more comprehensive and profound exploration.

Key words:

Oxygen-induced retinopathy; Disease model, animal; Retinopathy of prematurity; Retinal neovascularization

Contributor Information

Yang Ning
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Xing Yiqiao
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