Authors: Yang Ning, Xing Yiqiao
Cite as Chin J Exp Ophthalmol, 2018,36(1): 61-64.
Abstract [Download PDF] [Read Full Text]
Models of oxygen-induced retinopathy (OIR) have been built on several animals, including kitten, mouse, rat, rabbit, puppy and zebrafish.These models play an important role in studying the mechanisms and treatments of retinal neovascularization, which is partially mimicking the pathological process of retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). As the extensive application of transgenic technology, animal models of OIR will provide more evidences on investigating the retinal angiogenic diseases.However, none of these OIR models is perfect to simulate human ROP completely, which still needs more comprehensive and profound exploration.
Oxygen-induced retinopathy; Disease model, animal; Retinopathy of prematurity; Retinal neovascularization
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China
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