Application of iris fluorescein angiography combined with fundus fluorescein angiography in diabetic retinopathy with neovascular glaucoma

Authors:Li Shiqing,  Wang Zhili,  Li Ping,  Dong Yingli
DOI: 10.3760/cma.j.issn.2095-0160.2016.12.013
Published 2016-12-10
Cite as Chin J Exp Ophthalmol, 2016,34(12): 1112-1115.

Abstract                              [Download PDF] [Read Full Text]


Neovascular glaucoma (NVG) is secondary to retinal ischemia and hypoxia.Iris fluorescein angiography (IFA) can be used for early detection of NVG, but it can not reflect the condition of retinal blood vessels comprehensively.IFA combined with fundus fluorescein angiography (FFA) can detect the condition of retina and iris neovascularization comprehensively, but its application on diabetic retinopathy(DR) with NVG was rare in China.


This study was to evaluate the clinical application of IFA combined with FFA in proliferative diabetic retinopathy (PDR) patients with NVG.


A retrospectively study was designed.One hundred and thirty-three eyes with PDR were enrolled in Henan Eye Hospital from February 2013 to January 2016, including 100 eyes with no iris diseases, 21 eyes with rubeosis iridis, and 12 eyes with NVG.All eyes underwent ophthalmic examinations that included best-corrected visual acuity, intraocular pressure, slit lamp, IFA and FFA.The differences of IFA examination and slit lamp examination in the eyes with rubeosis iridis were compared and statistical analyzed by McNemar nonparametric test.


In this study, 100 eyes with no iris leakage were identified by IFA, 32 eyes with panretinal photocoagulation (PRP) treatment history had no retinal neovascularization and 68 eyes had retinal neovascularization; 21 rubeosis iridis eyes with iris leakage at pupillary border or on iris surface were observed at the early stage of IFA, and all the eyes were identified having retinal neovascularization according to FFA images; 12 NVG eyes were observed having iris neovascular leakage on iris surface at the early stage of IFA, and all the eyes were identified having retinal neovascularization according to FFA images.The detection rate of IFA examination on rubeosis iridis was 100%(21/21), which was higher than 71.43%(15/21) of slit lamp examination, and there was a significant difference between the two detection methods (P=0.03).


IFA combined with FFA can detect PDR with rubeosis iridis early, and it is helpful to guide the treatment timely.

Key words:

Diabetic retinopathy; Neovascular glaucoma; Fundus fluorescein angiography; Iris fluorescein angiography

Contributor Information

Li Shiqing
Henan Eye Institute, Henan Eye Hospital, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zheng Zhou 450003, China
Wang Zhili
Li Ping
Dong Yingli
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