Application of network pharmacology in ophthalmology

Authors: Liu Juping,  Li Xiaorong

DOI: 10.3760/cma.j.cn115989-20200224-00104
Published 2020-12-10
Cite as Chin J Exp Ophthalmol, 2020,38(12): 1083-1086.

Abstract

Network pharmacology is a branch of pharmacology, and it primarily studies the complex biological network relationship among drugs, genes, targets and diseases through biological network construction, network analysis and experimental verification of expected results.Network pharmacology has its unique advantage in the study of drugs with complex component in treating diseases with complex pathogenesis and is mainly used in research and development of new drugs, disclosure of drug mechanism, studies of traditional Chinese medicine and its compound, drug reorientation and toxicology.The reasearch of network pharmacology in treating eye diseases mainly involves bacterial conjunctivitis, retinal vein occlusion, diabetic retinopathy, retinitis pigmentosa, etc.The application prospect of network pharmacology in ophthalmology is mainly in exploring the effective substances, disease targets and pathways of traditional Chinese medicine in the treatment of ophthalmic diseases, drug repositioning and finding downstream targets in ophthalmic basic research.The research progress of network pharmacology in ophthalmology was reviewed, including the concept, research methods and application fields.

Key words:

Network pharmacology; Therapeutic target; Ophthalmology

Contributor Information

Liu Juping
Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China
Li Xiaorong
Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China
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Updated: December 18, 2020 — 7:37 am