Automated assisted clinical diagnosis of retinopathy of prematurity based on deep learning

Authors:Tong Yan,  Lu Wei,  Xu Yangtao,  Li Ying,  Wang Xiaoling,  Chen Changzheng,  Shen Yin
DOI: 10.3760/cma.j.issn.2095-0160.2019.08.011
Published 2019-08-10
Cite as Chin J Exp Ophthalmol, 2019,37(8): 647-651.

Abstract                              [View PDF] [Read Full Text]


To evaluate the application value of an intelligent fundus assisted diagnosis system for detecting retinopathy of prematurity (ROP) based on deep learning.


A total of 38 895 fundus images for premature infants screening were collected from Renmin Hospital of Wuhan University Eye Center and were labeled by 10 licensed ophthalmologists.A deep learning network model was established to acquire automatic classification of disease stages and plus disease.The accuracy, sensitivity and specificity of the algorithm were calculated to evaluate the performance of the artificial intelligence system for ROP automatic diagnosis.This study protocol was approved by Ethic Committee of Renmin Hospital of Wuhan University (No.WDRY2019-K032). Written informed consent was obtained from the guardians of the children before entering the study cohort.


The intelligent system achieved an accuracy of 0.931.Specifically, the accuracies in detecting demarcation line (stage Ⅰ) was 0.876, ridge (stage Ⅱ) was 0.942, ridge with extra retinal fibrovascular (stage Ⅲ) was 0.968, subtotal retinal detachment (stage Ⅳ) was 0.998, total retinal detachment (stage Ⅴ) was 0.999, vascular tortuosity and dilatation (plus disease) was 0.896, optic disc was 0.954, macular was 0.781, and laser scars were 0.974, respectively.


Deep learning algorithm can detect the stages and plus disease of ROP with excellent accuracy, and it provides the feasibility of applying the algorithm for ROP automated screening in clinical.

Key words:

Artificial intelligence; Deep learning; Retinopathy of prematurity; Assisted diagnosis

Contributor Information

Tong Yan
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Lu Wei
Xu Yangtao
Li Ying
Wang Xiaoling
Chen Changzheng
Shen Yin
(Read 77 times, 1 visits today)
Updated: December 28, 2022 — 8:33 am