Category: 2021, No. 08

Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration: a Meta-analysis

2021, No. 08, Clinical Science

Authors: Gu Hong,  Xu Zhangxing,  Shen Zhaomeng,  Li Zhiguo DOI: 10.3760/cma.j.cn115989-20191117-00498 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 729-736. Abstract                              [View PDF] [Read Full Text] Objective To systematically evaluate the association between the hepatic lipase (LIPC) gene rs10468017 polymorphism and susceptibility to age-related […]

Non-viral vector for gene therapy in inherited retinal degeneration

2021, No. 08, Review

Authors: Wei Xing,  Sui Ruifang DOI: 10.3760/cma.j.cn115989-20200627-00457 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 737-742. Abstract                              [View PDF] [Read Full Text] Inherited retinal degeneration (IRD), a group of diseases often causing irreversible blindness, with multiple pathogenesis, still lacks effective treatments currently.Development of effective […]

Role of circRNA in ophthalmic diseases

2021, No. 08, Review

Authors: Yang Guang,  Zhang Dan,  Ma Xiaopeng DOI: 10.3760/cma.j.cn115989-20191011-00437 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 743-748. Abstract                              [View PDF] [Read Full Text] Circular RNA (circRNA) is a closed loop molecule generated by the back-splicing of pre-mRNA.CircRNA can act as microRNA (miRNA) sponge […]

Related clinical trials and prospects of gene therapy for neovascular age-related macular degeneration

2021, No. 08, Review

Authors: Zhang Wei,  Yan Hua DOI: 10.3760/cma.j.cn115989-20210113-00033 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 749-754. Abstract                              [View PDF] [Read Full Text] Neovascular macular degeneration (nAMD) is one of the main eye diseases causing blindness in the elderly population.Early detection and early treatment are […]

Characteristics of autosomal dominant retinal diseases and gene therapy strategies

2021, No. 08, Review

Authors: Liu Yanbo, Pang Jijing DOI: 10.3760/cma.j.cn115989-20210329-00215 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 755-760. Abstract                              [View PDF] [Read Full Text] Inherited retinal diseases (IRDs), one type of the major eye diseases resulting in blindness, can be caused by more than 270 identified […]