Changes of brain function in resting-state in patients with nonproliferative diabetic retinopathy assessed by fractional low-frequency amplitude technique

Authors: Qi Chenxing,  Huang Xin,  Tong Yan,  Shen Yin
DOI: 10.3760/cma.j.cn115989-20190920-00406
Published 2020-09-10
Cite as Chin J Exp Ophthalmol, 2020,38(09): 760-765.

Abstract

Objective

To study the changes of brain function in patients with diabetic retinopathy (DR) by using resting-state functional magnetic resonance imaging (rs-fMRI) based on the fractional amplitude of low-frequency fluctuation (fALFF) method.

Methods

A cross-sectional study method was performed, 34 cases of non-proliferative DR patients treated in the Renmin Hospital of Wuhan University during July 2018 to March 2019 were collected.Meanwhile, 34 healthy volunteers with matched age, gender, and education years were recruited.All subjects were performed with conventional MRI scanning and rs-fMRI scanning, then the fALFF values in the whole brain were calculated, and the differences of neuronal activities between the two groups were explored.This research protocol was approved by the Ethic Committee of Renmin Hospital of Wuhan University, and written informed consent was obtained from each subject before any medical examination.

Results

The fALFF values of DR patients in the left inferior temporal gyrus, left cerebellum, right pallidum, left supplementary motor area, and right superior orbitofrontal gyrus were -0.58±0.29, -0.47±0.39, -0.37±0.24, -0.31±0.26 and 0.29±0.49, respectively, which were significantly higher than -1.03±0.29, -0.90±0.31, -0.78±0.22, -0.72±0.21 and-0.17±0.46 of the normal control (voxel level P<0.01, gaussian random field correction, cluster level P<0.05)(all at P<0.001).

Conclusions

Abnormal spontaneous neuronal activities occur in the left inferior temporal gyrus, left cerebellum, right pallidum, left supplementary motor area, and right superior orbitofrontal gyrus of DR patients.These abnormalities may associate with cognitive, vision and emotion.

Key words:

Diabetic retinopathy; Resting-state functional magnetic resonance imaging; Fractional amplitude of low-frequency fluctuation

Contributor Information

Qi Chenxing
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Huang Xin
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Tong Yan
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
Shen Yin
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
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Updated: September 15, 2020 — 2:19 am