Changes of neuroprotective factors and immune-related factors in aqueous humor of patients with primary open angle glaucoma

Authors: Zhang Yong,  Yang Qinmei,  Guo Feng,  Chen Xia,  Xie Lin

DOI: 10.3760/cma.j.issn.2095-0160.2018.04.012
Published 2018-04-10
Cite as Chin J Exp Ophthalmol, 2018,36(4): 284-288.

Abstract

Objective

To measure cytokine concentrations in aqueous humor of patients with primary open angle glaucoma (POAG) and cataract.

Methods

A cross-sectional study was performed under the informed consent of each subject from June to December in 2016 in Daping Hospital.A total of 24 cases of POAG patients served as the experimental group, while 22 cases of age related cataract patients served as control group.Concentrations of basic fibroblast growth factor (bFGF), monocyte chemoattractant protein-1 (MCP-1), brain derived neurotrophic factor (BDNF), soluble intercellular adhesion molecule-1 (sICAM-1), soluble neural cell adhesion molecule (sNCAM), and soluble vascular cell adhesion molecule-1 (sVCAM-1) with Luminex 200 were detected between the two groups.Then the comparison and the correlation analysis were performed between the two groups.

Results

Concentrations of MCP-1, sVCAM-1 and sNCAM in the experimental group were higher than those in the control group, with significant differences between them (P=0.017, 0.007, 0.001). The concentration of bFGF-2 in the experimental group was significantly lower than that in the control group (P=0.027). There was no significant difference in the expression levels of BDNF and sICAM-1 between the two groups (P>0.05). The expression levels of MCP-1, sICAM-1, sNCAM and sVCAM-1 were significantly associated with each other (all at P<0.05).

Conclusions

The expression levels of MCP-1, sVCAM-1 and sNCAM are elevated in POAG patients.POAG may be a neurodegenerative disease associated with neuroinflammation.

Key words:

Primary open angle glaucoma; Aqueous humor; Cytokine; Neurodegeneration

Contributor Information

Zhang Yong
Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Yang Qinmei
Guo Feng
Chen Xia
Xie Lin
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Updated: September 4, 2019 — 8:03 am