Choroidal vascular changes in high myopic patients using ultra-widefield SS-OCTA

Authors: Tu Shu, Yao Yuou, Zeng Qiaozhu, Zhao Mingwei
 

Citation

Tu Shu, Yao Yuou, Zeng Qiaozhu, et al. Choroidal vascular changes in high myopic patients using ultra-widefield SS-OCTA[J]. Chin J Exp Ophthalmol, 2024, 42(11):1020-1027. DOI: 10.3760/cma.j.cn115989-20230125-00026.

ABSTRACT                 [Download PDF] [Read Full Text]

Objective  To evaluate the three-dimensional choroidal vascularity index (3D-CVI) and choriocapillaris blood flow density (CCD) changes in patients with high myopia using ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA), and to investigate the relationship between axial length (AL) and choroidal vascular structure changes in high myopia.

Methods  A cross-sectional study was performed.A control group of 168 eyes of 168 normal subjects, and a high myopia group of 182 eyes of 182 high myopia patients were enrolled from November 2021 to October 2022 at the Peking University People’s Hospital.All subjects underwent an ultra-widefield SS-OCTA scan with an area of 24 mm × 20 mm.Full-field average and central area 3D-CVI and CCD were compared between the two groups.Correlation analysis and receiver operating characteristic curve analysis were used for 3D-CVI, CCD and AL, respectively.The AL cut-off values were determined when 3D-CVI and CCD were reduced.The study followed the Declaration of Helsinki, and the study protocol was approved by the Ethics Committee of Peking University People’s Hospital (No.2021PHB058-001).All participants voluntarily signed an informed consent form.

Results  The mean 3D-CVI and central 3D-CVI in the high myopia group were (31.37±7.85)% and (29.63±9.00)%, respectively, which were significantly lower than (32.86±4.25)% and (35.01±3.96)% in the control group ( t=2.241, 7.337; both at P<0.05).The mean CCD in the high myopia group was (45.59±3.63)%, which was significantly lower than (46.47±1.36)% in the control group ( t=3.038, P=0.003).Correlation analysis showed that mean 3D-CVI and CCD were negatively correlated with AL in the high myopia group ( r=-0.547, -0.657; both at P<0.001).Receiver operating characteristic curve analysis of 3D-CVI, CCD and AL suggested that the AL cut-off value of mean 3D-CVI-reduction was 28.93 mm and the area under the curve of 0.883 ( P<0.001, sensitivity=0.690, specificity=0.944).The AL cut-off value of mean CCD-reduction was 28.26 mm and the area under the curve was 0.884 ( P<0.001, sensitivity=0.793, specificity=0.832).

Conclusions  3D-CVI and CCD are both reduced in patients with high myopia.As AL increases, CCD changes earlier than 3D-CVI.

High myopia;Choroid;Swept-source optical coherence tomography angiography;Choroidal vascularity index;Choriocapillaris

Authors Info & Affiliations 

Tu Shu
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China
Yao Yuou
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China
Zeng Qiaozhu
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China
Zhao Mingwei
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China
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