Clinical features and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation

Authors:  Zhou Bo,  Lin Tingting,  Liu Xun,  Zhu Limin,  He Yanjin

 DOI: 10.3760/cma.j.issn.2095-0160.2018.06.009
Published 2018-06-10
Cite as Chin J Exp Ophthalmol, 2018,36(6): 442-448.

Abstract

Objective

To summarize the clinical characteristics and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation (LACC-HGT).

Methods

A retrospective study was adopted.Seventeen patients with lacrimal gland adenoid cystic carcinoma (LACC) were collected from August 2008 to March 2017 in Tianjin Medical University Eye Hospital.Hematoxylin-eosin staining and immunohistochemical staining were performed on tumor sections of 17 LACC patients.According to the pathology results, the patients were divided into LACC-HGT group (6 patients) and non-LACC-HGT (NLACC-HGT)group (11 patients), and the clinical characteristics and prognosis of the two groups were analyzed by using Fisher’s exact test and Log-Rank test.

Results

The medical histories, clinical features, imaging features, TNM staging and treatment protocols were not significantly different between the two groups (all at P>0.05). The 2-year local recurrence rate, 5-year distant metastasis rate and 5-year death rate of patients with LACC-HGT were significantly higher than patients with NLACC-HGT (all at P<0.05). Survival analysis results showed that the survival time of LACC-HGT group was obviously shorter than that of NLACC-HGT group.

Conclusions

LACC-HGT accelerate the invasion process of local recurrence and distant metastasis, and enhance the death rate.The detection of HGT components should be considered in the process of LACC diagnosis.

Key words:

Orbital neoplasms; Carcinoma, adenoid cystic; High-grade transformation; Clinical features; Prognosis

Contributor Information

Zhou Bo
Tianjin Medical University Eye Hospital, Tianjin 300384, China
Lin Tingting
Liu Xun
Zhu Limin
He Yanjin
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Updated: September 4, 2019 — 9:24 am