Authors: Zhou Bo, Lin Tingting, Liu Xun, Zhu Limin, He Yanjin
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To summarize the clinical characteristics and prognosis of lacrimal gland adenoid cystic carcinoma with high-grade transformation (LACC-HGT).
A retrospective study was adopted.Seventeen patients with lacrimal gland adenoid cystic carcinoma (LACC) were collected from August 2008 to March 2017 in Tianjin Medical University Eye Hospital.Hematoxylin-eosin staining and immunohistochemical staining were performed on tumor sections of 17 LACC patients.According to the pathology results, the patients were divided into LACC-HGT group (6 patients) and non-LACC-HGT (NLACC-HGT)group (11 patients), and the clinical characteristics and prognosis of the two groups were analyzed by using Fisher’s exact test and Log-Rank test.
The medical histories, clinical features, imaging features, TNM staging and treatment protocols were not significantly different between the two groups (all at P>0.05). The 2-year local recurrence rate, 5-year distant metastasis rate and 5-year death rate of patients with LACC-HGT were significantly higher than patients with NLACC-HGT (all at P<0.05). Survival analysis results showed that the survival time of LACC-HGT group was obviously shorter than that of NLACC-HGT group.
LACC-HGT accelerate the invasion process of local recurrence and distant metastasis, and enhance the death rate.The detection of HGT components should be considered in the process of LACC diagnosis.