Controversy of vitrectomy in the treatment of intraocular malignancy

Authors: Gao Jingge,  Chen Danian
DOI: 10.3760/cma.j.cn115989-20200311-00165
Published 2021-03-10
Cite as Chin J Exp Ophthalmol, 2021, 39(3): 249-253.

Abstract                                                 Read Full Text】    【Download PDF

Retinoblastoma (RB) and choroidal malignant melanoma are the most common primary intraocular malignancy in children and adults, respectively.Due to the advance in the diagnosis and treatment of intraocular tumors, the survival rate and survival time of the patients are significantly improved.The goal of the therapy for the patients of intraocular malignant tumors has gradually changed from simply saving life to trying to preserve eyeball on the basis of saving life.Although there are various treatment options for intraocular malignant tumors, eye salvage is still an great challenge for the patients with refractory tumors.In recent years, vitrectomy has been used again by some doctors to the treatment of refractory RB and choroidal malignant melanoma, which undoubtedly gives the hope of eye salvage to the patients with intraocular malignant tumors.However, this therapy arouse controversy because serious intraoperative or postoperative complications occurred in some patients.Ophthalmologists should select suitable indications for this surgery cautiously, perform the operation carefully, combine other chemotherapy and/or radiotherapy and local treatment and close follow-up if necessary.

Key words:

Retinoblastoma; Choroidal malignant melanoma; Vitrectomy; Tumor recurrence; Tumor metastasis; Controversy

Contributor Information

Gao Jingge
Research Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
Chen Danian
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System, Departments of Ophthalmology and Vision Science, Laboratory Medicine and Pathology, University of Toronto, Toronto M5G IX5, Canada
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Updated: March 16, 2021 — 7:10 am