Detection and analysis on serum antibodies for five common pathogenic microbes in patients with Posner-Schlossmarm syndrome

Authors: Chen Wenchieh,  Zhao Jun,  Zhu Tianhui,  Peng Shiming,  Huang Xiaosheng,  Mei Shaoyi,  Wang Yan

DOI: 10.3760/cma.j.issn.2095-0160.2017.12.012
Published 2017-12-10
Cite as Chin J Exp Ophthalmol, 2017,35(12): 1115-1119.

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Posner-Schlossman syndrome (PSS) is often recurrent and is a cause of blindness.The etiology of PSS remains to be elucidated.It is reported that there is a certain association between pathogenic microorganisms and PSS in rather small samples.


This study was to analyze the related serum antibody levels of cytomegalovirus (CMV), herpes simplex virus (HSV), rubella virus (RV), helicobacter pylori (HP) and anti-streptolysin O (ASO) and provide a clue for the study on pathogenesis and therapy of PSS.


A prospective cases-controlled study was carried out in Shenzhen Eye Hospital from December, 2014 to December, 2016 under the approval of Ethic Committee of this hospital and informed consent of each subject prior to initial of any medical examination.Peripheral blood samples were collected from 82 PSS patients as the PSS group and 100 age-and gender-matched healthy blood donors as the normal control group.The positive rates of serum CMV IgG, CMV IgM, HSV IgG, HSV IgM, RV IgG, RV IgM, HP IgG and HP IgM in the subjects were detected by indirect ELISA, and the positive rate of serum ASO antibody was determined by immuno-scatter turbidmetry.


The positive rates of serum CMV-IgG, CMV-IgM, HP-IgG, HP-IgM and ASO antibody were 22.0%, 17.1%, 22.0%, 17.1% and 17.1% in the PSS group, which were significantly higher than 5.0%, 0.0%, 10.0%, 2.0% and 7.0% in the normal control group (χ2=11.726, 18.496, 4.943, 12.766, 4.479, all at P<0.05). The positive rates of serum HSV-IgG, HSV-IgM, RV-IgG and RV-IgM in the PSS group were not significantly different from those in the normal control group (χ2=3.305, 0.986, 0.898, 0.503, all at P>0.05).


CMV, HP and hemolytic streptococcal infection may participate in the occurrence and development of PSS.

Key words:

Posner-Schlossman syndrome; Etiology; Cytomegalovirus; Herpes simplex virus; Rubella virus; Helicobacter pylori; Anti-streptolysin O; Antibody

Contributor Information

Chen Wenchieh
Shenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, China
Zhao Jun
Zhu Tianhui
Peng Shiming
Huang Xiaosheng
Mei Shaoyi
Wang Yan
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Updated: February 17, 2023 — 8:54 am