Discussion of possible interaction mechanisms between high myopia and glaucoma

Myopia is known to be one of risk factors of glaucoma, but the possible interaction mechanism between high myopia and glaucoma is below understood.High myopia is found to have some similar pathological changes to glaucoma, such as peripapillary detachment in pathologic myopia (PDPM), pit-like structure, peripapillary atrophy (PPA), thin lamina cribrosa, etc.In addition, high myopic eyes have higher intraocular pressure.According to trans-laminar pressure gradient hypothesis, high myopic eyes have higher trans-laminar pressure gradients than emmetropic eyes, which may be one of possible interaction mechanisms.In the study on genetics, the relationship between myopia and glaucoma has not been clearly elucidated.Recent researches of possible interaction mechanisms between high myopia and glaucoma were summarized in this paper.