Effect of compound anisodine on retinal function repair in diabetic retinopathy after panretinal photocoagulation

Authors: Zhang Moli,  Tian Bei,  Wei Wenbin
DOI: 10.3760/cma.j.issn.2095-0160.2015.02.012
Published 2015-02-10
Cite as Chin J Exp Ophthalmol, 2015,33(2): 155-158.

Abstract                               [Download PDF] [Read Full Text]


Panretinal photocoagulation (PRP) is an effective method for diabetic retinopathy (DR).However,PRP causes macular edema and visual impairment.The application of compound anisodine,a vascular dynamic drug can alleviate the adverse effect of PRP,but its effectiveness is not verified yet.


This study aimed to investigate the clinical therapeutic effect of compound anisodine on retinal functional damage following PRP in the eyes with non-proliferative diabetic retinopathy (NPDR).


A prospective cohort study was carried out from August 2013 to February 2014 in Beijing Tongren Hospital.One hundred and ten eyes with NPDR were included and PRP were performed.The operative eyes were randomized into the compound anisodine group (64 eyes) and control group (46 eyes).Compound anisodine solution of 2 ml was injected via temporal subcutaneous tissue since the second day after photocoagulation,and the injection was performed once per day for 4 courses in 3-day interval between each course (1 course for 14 days) in the compound anisodine group,and no any drug was used in the control group.The visual acuity,30° to 60° ring visual field and flash electroretinaogram (F-ERG) were examined before photocoagulation and 1 day,1 month and 2 months after photocoagulation to compare the retinal function between the two groups.


The vision acuity improved in 55 eyes in the compound anisodine group with the rate 85.94%,and that in the control group was 11 eyes with the rate 23.91%,showing a significant difference between the two groups (χ2=15.425,P=0.000).The mean sensitivities of visual field were (4.15±1.42),(3.94±1.40) and (4.81±1.41) dB in 1 day,1 month and 2 months after photocoagulation in the compound anisodine group,which were significantly higher than (3.76±1.52),(3.53±1.55) and (3.64±1.50) dB of the control group (t=1.39,1.44,1.15,all at P<0.05).The amplitudes of a-wave and b-wave of F-ERG were all higher in the compound anisodine group than those in the control group in various time points after photocoagulation (all at P<0.05).


The injection of compound anisodine via temporal subcutaneous tissue can relieve visual functional damage caused by PRP in NPDR eyes.

Key words:

Diabetic retinopathy/treatment; Laser coagulation; Postoperative complication; Retina/physiology; Compound anisodine

Contributor Information

Zhang Moli
Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Tian Bei
Wei Wenbin
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Updated: June 8, 2023 — 8:32 am