Effect of endogenous electric field on ocular cell behaviors

Authors: Liu Jun,  Han Jing,  Yan Hong
DOI: 10.3760/cma.j.issn.2095-0160.2015.06.016
Published 2015-06-10
Cite as Chin J Exp Ophthalmol, 2015,33(6): 556-559.

Abstract                              [Download PDF] [Read Full Text]

Corneal epithelial cells, lens epithelial cells, and retinal pigment epithelium cells contain a vast array of ion channels and pumps.The selective permeability to different ions generates endogenous electric fields and currents in those tissues.Abnormalities in the endogenous electric fields may underlie many ocular diseases, for example chronic corneal ulcers, posterior capsule opacity after cataract surgery, and retinopathies.How the electric fields influence the tissues and cells and participate in the occurrence of the ocular diseases is a hotspot of research in this field.This article briefly reviewed the mechanism of how the endogenous electrical activities are generated, the responses of ocular cells to applied electric fields, potential intracellular signaling mechanisms and clinical implications.Further understanding of this aspect is likely to offer new insights into ocular diseases.

Key words:

Electric field; Cell; Bioeffects

Contributor Information

Liu Jun
Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
Han Jing
Yan Hong
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