Effectiveness of intense pulsed light in the treatment of meibomian gland dysfunction

Authors: Liu Chang,  Zhang Chen,  Huang Yue,  Yang Ruibo,  Zhao Shaozhen
DOI: 10.3760/cma.j.issn.2095-0160.2019.03.005
Published 2019-03-10
Cite as Chin J Exp Ophthalmol, 2019,37(3): 185-189.

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To evaluate the effectiveness of intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD).


A prospective senal cases observational study was designed.Thirty patients with MGD (60 eyes)in the Tianjin Medical University Eye Hospital from October 2017 to April 2018 were enrolled.All the subjects received IPL therapy at baseline, 1 week and 3 weeks after the baseline, respectively.Before each treatment and 3 months after treatment, subjective symptoms (ocular surface disease index [OSDI] questionnaire, Standard Patient Evaluation of Eye Dryness [SPEED] questionnaire), palpebral margin score, lipiview ocular surface interferometer lipid layer thickness (LLT) measurement, tear meniscus height (TMH) and noninvasive tear film breakup time (NIBUT) measurement were performed to detect and assess the IPL treatment effect.The safety of the IPL treatment was evaluated through the visual acuity and intraocular pressure.


The OSDI score, SPEED score and the score of lipid excretion and secretion of meibomian gland before treatment were significantly higher than those of the other three time points (all at P<0.01). The TMH before treatment was significantly lower than that of the other three time points (all at P<0.01). No significant differences were obtained on first time NIBUT, blinking times and incomplete blink ratio among different time points (all at P>0.05). After treatment, the average thickness of tear film lipid layer was slightly increased, and the secretion of tarsal gland was improved.There were no adverse reactions during the treatment and follow-up, no changes in corrected vision, and the intraocular pressure fluctuated within the normal range.


IPL therapy can alleviate the symptoms and signs of dry eye of MGD patients, and the effect can last for at least 3 months.IPL is an effective and safe method in treatment of MGD.

Key words:

Meibomian gland dysfunction; Intense pulsed light; Therapeutic effect; Lipid thickness; Tear film

Contributor Information

Liu Chang
Tianjin Medical University Eye Hospital, Tianjin 300384, China
Zhang Chen
Huang Yue
Yang Ruibo
Zhao Shaozhen
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Updated: January 16, 2023 — 12:56 am