Efficacy of vitrectomy for vitreous amyloidosis

Authors:Li Zhongwen,  Wu Xuefang,  Pan Hanying,  Hao Xiaoyan,  Zhang xi
DOI: 10.3760/cma.j.issn.2095-0160.2016.08.011
Published 2016-08-10
Cite as Chin J Exp Ophthalmol, 2016,34(8): 720-723.

Abstract

Background

Vitreous amyloidosis is an autosomal dominant hereditary disease, often leads to reduction of visual acuity and affects life quality of patients.Vitrectomy is the main treatment for vitreous amyloidosis, but the analysis of curative efficacy in China is rarely reported.

Objective

The study was to observe and analyze the efficacy of vitrectomy for vitreous amyloidosis.

Methods

The clinical data of 11 eyes from 6 patients with vitreous amyloidosis who received vitrectomy from March 2011 to February 2013 in Affiliated Hospital of Guizhou Medical University.The best corrected visual acuity (BCVA), intraocular pressure (IOP), manifestations under the slit lamp microscope, findings of ocular fundus and results of fundus fluorescence angiography (FFA) were observed after surgery.Pathological examination for vitreous samples was carried by Congo red staining.

Results

Before surgery, the visual acuity was counting fingers for 30 cm in 5 eyes and hand movement for 30 cm in 6 eyes, and the mean IOP was (13.09±2.12)mmHg (1 mmHg=0.133 kPa). Fixed white flocks in vitreous and white membrane on the posterior lens capsule were seen under the slit lamp microscope.The BCVA remained 1.0 in 7 eyes and 0.8 in 4 eyes 1 week, 6 months and 2 years after vitrectomy, and the mean IOP was (13.32±2.07), (14.09±2.47), (12.32±1.87)mmHg at 1 week, 6 months and 2 years after vitrectomy, respectively.FFA showed a little fluorescein leakage at peripheral retinal vessel in all eyes at 1 week after vitrectomy but the leakage disappeared at 6 months after vitrectomy.The white flocks increased at peripheral retina in 4 eyes at 2 years after vitrectomy, but the BCVA remained the same in the eyes.Pathological examination of vitreous specimens comfirmed the diagnosis of vitreous amyloidosis.

Conclusions

Vitrectomy is an effective method for the treatment of vitreous amyloidosis, which can effectively improve the visual acuity of patients.Postoperative recurrence of vitreous amyloidosis appear in parts of patients, but the BCVA is unaffected.

Key words:

Amyloidosis, vitreous/surgery; Eye diseases/surgery; Vitrectomy; Vitreous body; Treatment outcome; Humans

Contributor Information

Li Zhongwen
Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
Wu Xuefang
Department of Pathology, Guizhou Provincial People’s Hospital, Guiyang 550002, China
Pan Hanying
Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
Hao Xiaoyan
Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
Zhang xi
Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
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