Evaluation of choroidal vascularity index and subfoveal choroidal thickness in eyes with chronic central serous chorioretinopathy and their normal fellow eyes

Authors: Sun Gongpeng,  Yi Zuohuizi,  Liu Juejun,  Chen Changzheng
DOI: 10.3760/cma.j.cn115989-20200926-00667
Published 2023-02-10
Cite as Chin J Exp Ophthalmol, 2023, 41(2): 160-165.

Abstract                             [Download PDF] [Read Full Text]

Objective

To observe the choroidal vascular changes of chronic central serous chorioretinopathy (cCSC), and analyze their correlations with central macular thickness (CMT).

Methods

A cross-sectional study was adopted.Seventy-six eyes of 38 patients with monocular cCSC who were treated in Renmin Hospital of Wuhan University from March 2018 to December 2019 were enrolled, and 30 eyes of 30 normal control matched with age, gender, and spherical equivalent (SE) were included.Choroidal images of all subjects, and the CMT, subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), total choroidal area (TCA), choroidal stromal area (SA), and choroidal luminal area (LA) were measured by Heidelberg enhanced depth imaging optical coherence tomography.The differences in SFCT, LA, SA, TCA, CMT and CVI between the cCSC eye, fellow eye and normal eye, as well as the correlation between SFCT and CVI, SFCT and CMT, and CVI and CMT were analyzed.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Renmin Hospital of Wuhan University (No.WDRY2020-K234).

Results

The CVI and the SFCT of the cCSC eyes, fellow eyes and normal eyes were (71.67±5.60)% and 483.82(409.01, 550.87)μm, (68.33±3.85)% and 444.66(351.25, 505.15)μm, (64.70±1.88)% and 373.46(327.98, 405.48)μm, respectively.The CMT, SFCT, TCA, LA, CVI in cCSC eyes were significantly higher than those in the contralateral eyes and normal control eyes, while SFCT, TCA, LA, CVI in the contralateral eyes were higher than those in normal control eyes (all at P<0.05). Pairwise comparison among the three groups showed no significant difference in SA (all at P>0.05). Correlation analysis showed that in cCSC eyes, SFCT was strongly positively correlated with CVI (rs=0.703, P<0.001), and there was no correlation between CMT and SFCT (rs=0.181, P=0.278), or CMT and CVI (r=0.231, P=0.164).

Conclusions

The SFCT and CVI are higher in cCSC and the fellow eyes compared with normal eyes, and the choroidal vessels are significantly dilated in cCSC patients.The SFCT and CVI of the cCSC eye are slightly higher in comparison with the fellow eye.CMT is not correlated with SFCT or CVI in cCSC eyes.

Key words:

Central serous chorioretinopathy; Tomography, optical coherence; Choroid; Choroidal vascularity index; Subfoveal choroidal thickness; Central macular thickness

Contributor Information

Sun Gongpeng

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

Yi Zuohuizi

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

Liu Juejun

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

Chen Changzheng

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

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