HLA-B27 positive spinal arthritis-related eye disease

Spondyloarthritis (SpA), an inflammatory rheumatic disease, is closely associated with human leukocyte antigen B27 (HLA-B27), which can affect the sacroiliac joints, spine, peripheral joints, and periarticular entheses, and is often accompanied by multisystem involvement beyond the joints.Ocular manifestations are common extra-articular features in HLA-B27 positive SpA, with prevalent acute anterior uveitis, and other ocular diseases such as episcleritis, scleritis, conjunctivitis, keratitis and so on.The etiology and pathogenesis of ocular complications in HLA-B27 positive SpA are not fully understood.Current research suggests that genetic susceptibility, alterations in gut microbiota, and cytokine imbalances might play significant roles.This review summarizes the pathogenesis, epidemiology, clinical characteristics, and treatment of ocular diseases associated with HLA-B27 positive SpA.

Human leukocyte antigen B27; Spondyloarthritis; Uveitis; Ocular diseases