Paying attention to the prognosis guiding effects of CNV dynamic changes based-OCT angiography in neovascular age-related macular degeneration after antiangiogenic therapy

Authors: Zhao Zhi,  Sun Xiaodong

DOI: 10.3760/cma.j.issn.2095-0160.2018.01.001
Published 2018-01-10
Cite as Chin J Exp Ophthalmol, 2018,36(1): 1-4.

Abstract

Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is a first line therapy for neovascular age-related macular degeneration (nAMD). However, how to predict the respond for anti-VEGF treatment is still a challenge in clinic practice.Optical coherence tomography angiography (OCTA) can offer dynamic following-up for choroidal neovascularization (CNV) in nAMD after antiangiogenic therapy.The change of vascular morphology based on OCTA enriches the novel theory of prognosis for tveatment of nAMD and can be considered as a biomarker of neovascularization in vivo, which can help us to evaluate the activity of CNV and understand the mechanism of anti-VEGF resistance.So, OCTA should be a standard strategy during the diagnosis, treatment and follow-up of nAMD.We should pay more attention to the guiding significance in the prognosis evaluation of nAMD basis on character of vascular morphology by OCTA following antiangiogenic therapy.

Key words:

Tomography, optical coherence; Age-related macular degeneration, neovascular/drug therapy; Choroidal neovascularization/drug therapy; Prognosis; Vascular endothelial growth factor; Optical coherence tomography angiography

Contributor Information

Zhao Zhi
Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China (now in Affliated People’s Hospital of Jiangsu University)
Sun Xiaodong
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