Progress in the application of antimicrobial peptides in ocular surface infectious diseases

Authors: Xu Sanhua,  Pei Chonggang,  Shao Yi
DOI: 10.3760/cma.j.cn115989-20220210-00047
Published 2024-04-10
Cite as Chin J Exp Ophthalmol, 2024, 42(4): 393-396.

Abstract                             【Download PDF】 【Read Full Text

Due to their prolonged exposure to the external environment, eyes are susceptible to various infectious diseases of the ocular surface.In recent years, the resistance of pathogens to antimicrobial agents has led to poor treatment outcomes and significant deterioration in patients’ vision and quality of life.Nowadays, ocular surface infectious diseases have become a global public health concern, necessitating the search for a safe and effective treatment.Antimicrobial peptides (AMPs), which act as antibiotic analogues, exhibit broad-spectrum antibacterial activity and are effective against a range of microbial infections, including bacteria, viruses, fungi, and parasites.AMPs play a crucial role in combating ocular surface infections.This review discusses the structure and function of AMPs, the mechanism of action of AMPs in ocular surface infections, the role of endogenous AMPs in fighting various ocular surface pathogens, the impact of exogenously induced AMPs on ocular surface infections, and recent research advances in AMPs.

Key words:

Antimicrobial peptides; Cornea; Infections; Ocular surface

Contributor Information

Xu Sanhua

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Pei Chonggang

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Shao Yi

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Shao Yi is working at Department of Ophthalmology, Eye &

ENT Hospital of Fudan University, Shanghai 200030, China

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