Progress of treatment for large idiopathic macular holes

Authors: Fan Xiaoe,  Ren Xinjun,  Li Xiaorong
DOI: 10.3760/cma.j.cn115989-20190129-00039
Published 2022-01-10
Cite asChin J Exp Ophthalmol, 2022, 40(1): 88-92.

Abstract

Size of the macular hole (MH) is an important factor affecting the treatment of MH. MH with a diameter >400 mm was defined as large MH. Pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling or intravitreal gas tamponade, which can effectively relieve the traction of vitreoretinal interface, is the standard surgical technique for idiopathic full-thickness macular hole (FTMH), but its efficacy on refractory large FTMH is very limited. In order to obtain ideal anatomical healing and functional recovery of large FTMH, new surgical strategies, such as reversal of retinal internal limiting membrane (ILM), expanded removal of ILM, transplantation of different tissue valves, application of mesenchymal stem cells and so on, have been the focus of researchers in the field of fundus diseases. More targeted and personalized treatment is the development trend of treatment for large FTMH.The progress of ILM flipping surgery, expansion of ILM removal, transplantation of different tissue valves, biomaterials and other auxiliary techniques in the treatment of large diameter FTMH were reviewed in this article.

Key words:

Retinal perforations/surgery; Vitreoretinal surgery; Review

Contributor Information

Fan Xiaoe

Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research Center of Ophthalmology and Visual Science, Tianjin 300384, China

Ren Xinjun

Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research Center of Ophthalmology and Visual Science, Tianjin 300384, China

Li Xiaorong

Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research Center of Ophthalmology and Visual Science, Tianjin 300384, China

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