Progress on Nrf2 pathway in diabetic retinopathy

Authors:Zhang Siyuan,  Lyu Hongbin
DOI: 10.3760/cma.j.issn.2095-0160.2016.05.017
Published 2016-05-10
Cite as Chin J Exp Ophthalmol, 2016,34(5): 471-475.

Abstract

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus, which leads to vision loss or even blindness.Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor and plays an important role in oxidative stress and tissue injury associated with inflammation.More and more evidences show that Nrf2 play an important role in the onset and development of DR.This paper reviewed the role of Nrf2 pathway in diabetes mellitus and DR, and correlation between Nrf2 pathway and vascular endothelial growth factor (VEGF) expression.

Key words:

Nuclear factor erythroid 2-related factor 2; Diabetic retinopathy; Oxidative stress; Vascular endothelial growth factor

Contributor Information

Zhang Siyuan
Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
Lyu Hongbin
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Updated: October 9, 2019 — 3:01 am