Recent advance research progress on complement factor I and age-related macular degeneration

Auhtors: Wang Qin,  Zhao Haisheng,  Li Li
DOI: 10.3760/cma.j.issn.2095-0160.2015.02.019
Published 2015-02-10
Cite as Chin J Exp Ophthalmol, 2015,33(2): 189-192.

Abstract                                [Download PDF] [Read Full Text]

Age-related macular degeneration (AMD) is one of the most important diseases that cause vision loss among older patients in developed countries. As the progress of population aging in China, the incidence of AMD is increasing. The activation of the complement system plays an important role in AMD pathogenesis. Complement factor Ⅰ (CFI) is an important complement regulator. In recent years, there have been numerous studies about CFI single-nucleotide polymorphisms (SNPs) and AMD. The mechanism of CFI and the association between CFI polymorphisms and AMD were reviewed in the article.

Key words:

Age-related macular degeneration; Complement system; Complement factor Ⅰ; Single-nucleotide polymorphisms

Contributor Information

Wang Qin
Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Zhao Haisheng
Li Li
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