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Age-related macular degeneration (AMD) is one of the most important diseases that cause vision loss among older patients in developed countries. As the progress of population aging in China, the incidence of AMD is increasing. The activation of the complement system plays an important role in AMD pathogenesis. Complement factor Ⅰ (CFI) is an important complement regulator. In recent years, there have been numerous studies about CFI single-nucleotide polymorphisms (SNPs) and AMD. The mechanism of CFI and the association between CFI polymorphisms and AMD were reviewed in the article.