Regulation of Toll-like receptors in fungal keratitis

Authors: Wang Luping,  Wu Xinyi
DOI: 10.3760/cma.j.issn.2095-0160.2015.10.019
Published 2015-10-10
Cite as Chin J Exp Ophthalmol, 2015,33(10): 953-956.

Abstract                             [Download PDF] [Read Full Text]

Fungal keratitis (FK), a potential blinding disease, has been difficult to treat due to the limited number of approved antifungal drugs and the taxing dosing regimen.Toll-like receptors (TLRs) function as the pattern recognition receptors (PRRs) in mammals and play an essential role in the recognition of fungal components.There is a great amount of evidence that TLRs initiate the innate immunity in the FK.Furthermore, TLRs also play roles in shaping fungal-specific humoral and cellular adaptive immune responses.This review described the recent advances in interaction between TLRs and non-TLRs signal transduction, negative regulator and function of TLRs in corneal fungal infection.

Key words:

Keratitis, fungal; Toll-like receptors; Signal transduction; Nod-like receptors; Dectin-1; Immune tolerance

Contributor Information

Wang Luping
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, China
Wu Xinyi
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