Research advance on application of in vivo confocal microscopy in herpes simplex keratitis

Herpes simplex keratitis(HSK) is the first inflammatory cause for uniocular blindness.The clinical inspection methods commonly used are limited to general observation, while in vivo confocal microscopy(IVCM) can provide details of cellular changes in an intravital HSK.IVCM not only gives more clinical evidence for pathology studying of HSK, but also serves as a new technology for the whole progress of HSK epidemiology.This article reviewed current researches of applying IVCM for HSK clinical observation and summarized these latest results.Morphological changes of each layer of the cornea, the specificity of these changes and clinical application of IVCM had been discussed in this article.