The role of thrombospondin-1 in corneal wound healing

Authors: Ni Shuang,  Liu Ping
DOI: 10.3760/cma.j.issn.2095-0160.2015.05.019
Published 2015-05-10
Cite as Chin J Exp Ophthalmol, 2015,33(5): 478-480.

Abstract                              [Download PDF] [Read Full Text]

Thrombospondin-1(THBS-1), a kind of extracellular matrix proteins, whose biological action played an important role in corneal wound healing has became a research highlight.The currently research findings showed that THBS-1 could promote the healing of epithelium, stroma and endothelium through activating the transforming growth factor-β1(TGF-β1) which can accelerate cell proliferation, promote stroma forming and inducing cell migration.It is worthful in clinical treatment of al1 kinds of corneal wound healing.Now we summarized the research developments which have been acquired in the field recently in this article.

Key words:

Thrombospondin-1; Transforming growth factor-β; Corneal/wound healing

Contributor Information

Ni Shuang
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Liu Ping
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